Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI:10.1016/S1875-5364(25)60850-8

Mengtian Li , Norbu Kelsang , Yongqin Zhao , Wensen Li , Feng Zhou , Pema , Lu Cui , Xianjie Bao , Qian Wang , Xin Feng , Minghua Yang

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引用次数: 0

Abstract

Five meroterpenoids, rhodonoids K–M (1–2), daurichromene E (3), and grifolins A–B (4–5), together with seven known compounds (6–12), were isolated from Rhododendron anthopogonoides. The chemical structures of these compounds were elucidated through comprehensive analysis of high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet (UV), infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) data. Their absolute configurations were determined by comparing experimental electronic circular dichroism (ECD) spectra with computed values. Notably, compounds 1 and 3 demonstrated significant inhibitory effects on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. These compounds markedly suppressed the mRNA expressions of inflammatory factors, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) while also down-regulating the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).

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五种杜鹃花新萜类化合物及其抗炎活性

从anthopogonoides中分离得到5个meroterpenoids， rhodonoids K-M (1-2), daurichromene (3), grifolins A-B（4-5）和7个已知化合物（6-12）。通过高分辨率电喷雾电离质谱（HR-ESI-MS）、紫外（UV）、红外光谱（IR）和核磁共振（NMR）数据的综合分析，对这些化合物的化学结构进行了鉴定。通过比较实验电子圆二色性（ECD）光谱与计算值，确定了它们的绝对构型。值得注意的是，化合物1和3对RAW264.7细胞中脂多糖（LPS）诱导的炎症有明显的抑制作用。这些化合物显著抑制炎症因子，包括白细胞介素(IL)-1β、IL-6和肿瘤坏死因子-α (TNF-α) mRNA的表达，同时下调诱导型一氧化氮合酶（iNOS）和环氧合酶-2 （COX-2）蛋白的表达。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.