Nonswelling Lubricative Nanocolloidal Hydrogel Resistant to Biodegradation.

IF 36.3 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2025-07-11 DOI:10.1007/s40820-025-01830-0

Tiantian Ding,Chunxia Ren,Liyuan Meng,Guoyong Han,Yao Xue,Wenlong Song,Daowei Li,Hongchen Sun,Bai Yang,Yunfeng Li

引用次数: 0

Abstract

Hydrogels derived from biopolymers have numerous applications in bioengineering, drug delivery, wound healing, and wearable devices. Yet, their strong swelling and uncontrollable degradation stimulate the development of hydrogels that overcome these limitations. Here, we report nanocolloidal hydrogels formed from nanoparticles of methacryloyl-modified biopolymers that exhibit resistance to swelling and enzymatic degradation both in vitro and in vivo, along with exhibiting a broad-range of mechanical and lubrication properties, wear resistance and biocompatibility. The nonswelling behavior of nanocolloidal hydrogels takes origin in the resistance to swelling of their hydrophobic regions which are resulted from the nanophase of hydrophobic methacryloyl groups in the interior of the constituent nanoparticles. The developed approach to the preparation of nanocolloidal hydrogel with greatly enhanced properties will have applications in long-term drug delivery and cell culture, soft tissue augmentation, and implantable bioelectronics.

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耐生物降解的非膨胀润滑纳米胶体水凝胶。

生物聚合物衍生的水凝胶在生物工程、药物输送、伤口愈合和可穿戴设备中有着广泛的应用。然而，它们强烈的膨胀和不可控的降解刺激了水凝胶的发展，克服了这些限制。在这里，我们报道了由甲基丙烯酰修饰的生物聚合物纳米颗粒形成的纳米胶体水凝胶，在体外和体内都表现出抗膨胀和酶降解的能力，同时表现出广泛的机械和润滑性能，耐磨性和生物相容性。纳米胶体水凝胶的不膨胀行为源于其疏水区域的抗膨胀性，这是由组成纳米颗粒内部的疏水甲基丙烯基纳米相引起的。这种制备纳米胶体水凝胶的方法具有极大的增强性能，将在长期药物输送和细胞培养、软组织增强和植入式生物电子学等领域得到应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.