An Anti-NH2 Terminal of α-enolase Antibody-positive Hashimoto's Encephalopathy with Bilateral Basal Ganglia Lesions: A Case Report and Literature Review.

Yu Matsuda, Mitsuhiro Kainaga, Mizue Maeda, Hideki Kitao, Shinichi Tokushige, Ayumi Uchibori, Chizuko Oishi, Yaeko Ichikawa
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Abstract

Hashimoto's encephalopathy (HE) is a type of encephalopathy characterized by neuropsychiatric symptoms, high serum anti-thyroid antibody concentrations, and good responsiveness to immunotherapy. We herein report a rare case of HE with positive serum anti-NH2 terminal of α-enolase (NAE) antibodies and abnormal findings in the bilateral basal ganglia on brain magnetic resonance imaging (MRI). In cases presenting with isolated lesions in the basal ganglia, HE should not be excluded from the differential diagnosis, particularly when other causes are excluded and serum anti-thyroid antibodies are elevated. In such cases, testing for anti-NAE antibodies may aid in the diagnosis.

α-烯醇化酶抗体阳性桥本脑病伴双侧基底节区病变的抗nh2末端:1例报告并文献复习。
桥本脑病(Hashimoto's encephalopathy, HE)是一种以神经精神症状、血清抗甲状腺抗体浓度高、对免疫治疗反应良好为特征的脑病。我们报告一例罕见的HE患者血清α-烯醇化酶(NAE)抗nh2末端抗体阳性,脑磁共振成像(MRI)显示双侧基底神经节异常。在基底节区表现为孤立病变的病例中,不应将HE排除在鉴别诊断之外,特别是在排除其他原因和血清抗甲状腺抗体升高的情况下。在这种情况下,检测抗nae抗体可能有助于诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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