Inflammation's impact on the interaction between oligodendrocytes and axons.

Discovery immunology Pub Date : 2025-04-29 eCollection Date: 2025-01-01 DOI:10.1093/discim/kyaf008
Tabitha R F Green, Marieke Pingen, Julia M Edgar
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引用次数: 0

Abstract

Oligodendrocytes are responsible for the myelination of axons and providing trophic and metabolic support to the myelinated axon. They also interact with immune effector cells, including microglia and T cells, hence, are involved in central nervous system immune regulation. Given the crucial roles for oligodendrocytes and myelin in axonal function and maintenance, dysfunction, whether through cell death, myelin injury and loss, or failure in normal myelin formation, impairs neurological function. In diseases such as multiple sclerosis, the leukodystrophies, and viral infection, neuroinflammation is an important effector of myelin injury, having secondary consequences for the myelinated axon. In this review, we discuss the role of oligodendrocytes in health and inflammatory disease, with a focus on the interplay between inflammation and oligodendrocyte-axon interactions.

炎症对少突胶质细胞与轴突相互作用的影响。
少突胶质细胞负责轴突的髓鞘形成,并为髓鞘轴突提供营养和代谢支持。它们还与免疫效应细胞相互作用,包括小胶质细胞和T细胞,因此参与中枢神经系统的免疫调节。鉴于少突胶质细胞和髓磷脂在轴突功能和维持中的关键作用,功能障碍,无论是通过细胞死亡、髓磷脂损伤和丢失,还是正常髓磷脂形成失败,都会损害神经功能。在多发性硬化症、白质营养不良和病毒感染等疾病中,神经炎症是髓磷脂损伤的重要效应,对髓鞘轴突有继发性影响。在这篇综述中,我们讨论了少突胶质细胞在健康和炎症疾病中的作用,重点讨论了炎症和少突胶质细胞-轴突相互作用之间的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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