Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death.

IF 6.5 2区 医学 Q1 IMMUNOLOGY
Oncoimmunology Pub Date : 2025-12-01 Epub Date: 2025-07-10 DOI:10.1080/2162402X.2025.2531113
Karla Alvarez-Valadez, Jonathan G Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
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引用次数: 0

Abstract

Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger cholesterol accumulation within lysosomes followed by lysosomal membrane permeabilization, ultimately leading to the activation of immunogenic cell death (ICD). This, in turn, triggers a T cell-mediated adaptive immune response that facilitates significant tumor control.

Abstract Image

Abstract Image

抗抑郁药破坏胆固醇稳态可诱导免疫原性细胞死亡。
舍曲林和茚丙林是两种抗抑郁药,作为5 -羟色胺再摄取抑制剂的功能,已经显示出很有希望的抗癌潜力,尽管它们的确切作用机制尚不清楚。这两种化合物都会触发溶酶体内的胆固醇积累,随后溶酶体膜渗透,最终导致免疫原性细胞死亡(ICD)的激活。这反过来又触发了T细胞介导的适应性免疫反应,促进了显著的肿瘤控制。
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来源期刊
Oncoimmunology
Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY
CiteScore
12.50
自引率
2.80%
发文量
276
审稿时长
24 weeks
期刊介绍: OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.
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