{"title":"Analysis of the current status of difficult crossmatching and the causes of blood mismatch from 2017-2021.","authors":"Li Xiong, Yu Sun","doi":"10.1177/09287329251352992","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Blood transfusion is a critical medical intervention, and accurate cross-matching is essential to prevent adverse reactions. However, difficult cross-matching (DCM), often caused by irregular antibodies, poses significant challenges, particularly in patients with prior transfusions, pregnancies, or certain medical conditions.</p><p><strong>Objective: </strong>To analyze the incidence and causes of DCM from 2017 to 2021 and propose strategies to improve transfusion safety and compatibility.</p><p><strong>Methods: </strong>A total of 363 patients who underwent difficult cross-matching due to incompatible blood matching between January 2017 and December 2021 were selected as the study population. Pre-transfusion testing was conducted for all patients to observe patterns in difficult cross-matching, assess the causes of blood mismatch, and analyze irregular antibody detection results. Based on these findings, specific treatment measures were proposed to address the causes of incompatibility.</p><p><strong>Results: </strong>Most DCM cases occurred in females (81.27%), especially under 45 years of age, with obstetrics and gynecology being the most affected departments. Positive irregular antibodies were identified in 86.50% of cases, mainly from the Rh blood group system (42.99%), followed by autoantibodies (19.43%) and other blood group antibodies. Effective strategies included selecting antigen-negative blood, warming transfusions for cold autoantibodies, and using saline for pseudoagglutination.</p><p><strong>Conclusion: </strong>Irregular antibodies are the main cause of DCM. Accurate identification and tailored transfusion strategies are essential to ensure safety. Greater awareness and improved screening can reduce risks and enhance clinical outcomes.</p>","PeriodicalId":48978,"journal":{"name":"Technology and Health Care","volume":" ","pages":"9287329251352992"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Technology and Health Care","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/09287329251352992","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Blood transfusion is a critical medical intervention, and accurate cross-matching is essential to prevent adverse reactions. However, difficult cross-matching (DCM), often caused by irregular antibodies, poses significant challenges, particularly in patients with prior transfusions, pregnancies, or certain medical conditions.
Objective: To analyze the incidence and causes of DCM from 2017 to 2021 and propose strategies to improve transfusion safety and compatibility.
Methods: A total of 363 patients who underwent difficult cross-matching due to incompatible blood matching between January 2017 and December 2021 were selected as the study population. Pre-transfusion testing was conducted for all patients to observe patterns in difficult cross-matching, assess the causes of blood mismatch, and analyze irregular antibody detection results. Based on these findings, specific treatment measures were proposed to address the causes of incompatibility.
Results: Most DCM cases occurred in females (81.27%), especially under 45 years of age, with obstetrics and gynecology being the most affected departments. Positive irregular antibodies were identified in 86.50% of cases, mainly from the Rh blood group system (42.99%), followed by autoantibodies (19.43%) and other blood group antibodies. Effective strategies included selecting antigen-negative blood, warming transfusions for cold autoantibodies, and using saline for pseudoagglutination.
Conclusion: Irregular antibodies are the main cause of DCM. Accurate identification and tailored transfusion strategies are essential to ensure safety. Greater awareness and improved screening can reduce risks and enhance clinical outcomes.
期刊介绍：
Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered:
1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables.
2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words.
Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics.
4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors.
5.Letters to the Editors: Discussions or short statements (not indexed).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
