Assessing Brain Injury After Extra-Axial Brain Tumor Resection: Circulating Neurofilament Light Levels, Neurological Deficits, and Fatigue.

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Neurosurgery Pub Date : 2025-07-10 DOI:10.1227/neu.0000000000003612

Isak Michaëlsson, Tobias Hallén, Dan Farahmand, Ubah Mahamud, Kaj Blennow, Henrik Zetterberg, Asgeir S Jakola, Thomas Skoglund

{"title":"Assessing Brain Injury After Extra-Axial Brain Tumor Resection: Circulating Neurofilament Light Levels, Neurological Deficits, and Fatigue.","authors":"Isak Michaëlsson, Tobias Hallén, Dan Farahmand, Ubah Mahamud, Kaj Blennow, Henrik Zetterberg, Asgeir S Jakola, Thomas Skoglund","doi":"10.1227/neu.0000000000003612","DOIUrl":null,"url":null,"abstract":"Background and objectives: Circulating brain-injury biomarkers have recently gained increased interest, as new ultrasensitive measurement techniques have enabled quantification of brain injury through blood sampling. This prospective study explores relationships between plasma levels of the axonal injury biomarker neurofilament light chain (NfL) and postoperative outcomes, including new neurological deficits and fatigue, in patients undergoing extra-axial brain tumor surgery. In addition, we aimed to establish the temporal profile of changes in NfL levels after surgery.Methods: We included 41 adult patients scheduled for surgery for meningiomas or vestibular schwannomas. Plasma concentrations of NfL were measured the day before surgery and on postoperative days 1, 10, 30, and 60, with new neurological deficits assessed on day 1 postsurgery. Fatigue was measured using the Multidimensional Fatigue Inventory before and 6 months after surgery.Results: NfL levels peaked on day 10 after surgery, and patients with new neurological deficits postsurgery had higher NfL levels on days 10, 30, and 60 relative to those without new deficits. NfL levels at day 10 had the highest sensitivity and specificity in relation with new neurological deficits. No association was found between postoperative NfL levels and development of fatigue.Conclusion: The results suggest measuring NfL level as a promising method for quantifying structural brain damage associated with extra-axial tumor surgery. However, these findings did not reveal associations between elevated NfL levels and postoperative fatigue.","PeriodicalId":19276,"journal":{"name":"Neurosurgery","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1227/neu.0000000000003612","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objectives: Circulating brain-injury biomarkers have recently gained increased interest, as new ultrasensitive measurement techniques have enabled quantification of brain injury through blood sampling. This prospective study explores relationships between plasma levels of the axonal injury biomarker neurofilament light chain (NfL) and postoperative outcomes, including new neurological deficits and fatigue, in patients undergoing extra-axial brain tumor surgery. In addition, we aimed to establish the temporal profile of changes in NfL levels after surgery.

Methods: We included 41 adult patients scheduled for surgery for meningiomas or vestibular schwannomas. Plasma concentrations of NfL were measured the day before surgery and on postoperative days 1, 10, 30, and 60, with new neurological deficits assessed on day 1 postsurgery. Fatigue was measured using the Multidimensional Fatigue Inventory before and 6 months after surgery.

Results: NfL levels peaked on day 10 after surgery, and patients with new neurological deficits postsurgery had higher NfL levels on days 10, 30, and 60 relative to those without new deficits. NfL levels at day 10 had the highest sensitivity and specificity in relation with new neurological deficits. No association was found between postoperative NfL levels and development of fatigue.

Conclusion: The results suggest measuring NfL level as a promising method for quantifying structural brain damage associated with extra-axial tumor surgery. However, these findings did not reveal associations between elevated NfL levels and postoperative fatigue.

查看原文本刊更多论文

评估轴外脑肿瘤切除后的脑损伤：循环神经丝光水平、神经功能缺损和疲劳。

背景和目的：循环脑损伤生物标志物最近获得了越来越多的兴趣，因为新的超灵敏测量技术可以通过血液采样来量化脑损伤。这项前瞻性研究探讨了轴外脑肿瘤手术患者轴突损伤生物标志物神经丝轻链（NfL）血浆水平与术后预后（包括新的神经功能缺损和疲劳）之间的关系。此外，我们的目的是建立术后NfL水平变化的时间概况。方法：我们纳入了41例计划手术治疗脑膜瘤或前庭神经鞘瘤的成年患者。术前及术后第1、10、30、60天测量血浆中NfL浓度，术后第1天评估新的神经功能缺损。术前和术后6个月使用多维疲劳量表测量疲劳程度。结果：NfL水平在术后第10天达到峰值，术后出现新神经功能缺损的患者在第10、30和60天的NfL水平高于无新神经功能缺损的患者。第10天的NfL水平与新的神经功能缺陷相关的敏感性和特异性最高。术后NfL水平与疲劳发展无关联。结论：测定NfL水平是一种很有前景的量化轴外肿瘤手术相关脑结构损伤的方法。然而，这些发现并未揭示NfL水平升高与术后疲劳之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurosurgery 医学-临床神经学

CiteScore

8.20

自引率

6.20%

发文量

898

审稿时长

2-4 weeks

期刊介绍： Neurosurgery, the official journal of the Congress of Neurological Surgeons, publishes research on clinical and experimental neurosurgery covering the very latest developments in science, technology, and medicine. For professionals aware of the rapid pace of developments in the field, this journal is nothing short of indispensable as the most complete window on the contemporary field of neurosurgery. Neurosurgery is the fastest-growing journal in the field, with a worldwide reputation for reliable coverage delivered with a fresh and dynamic outlook.