Healing wounds with a multimodal botanical hydrogel: a clinical outcomes comparison study.

IF 1.7 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2025-07-01 DOI:10.12968/jowc.2025.0185

Sung Ho Steve Bae, Windy Cole, Imaze M Davis, Dmitry Sandler, J David Warren, Janet S Mackenzie

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引用次数: 0

Abstract

Objective: Diabetic foot wounds pose many challenges during the healing process and often become hard-to-heal (chronic) wounds. This study compared a novel botanical hydrogel with a widely used hydrogel to determine both its non-inferiority and impact on the progress of diabetic foot wounds.

Method: The study was a prospective, double-blinded, randomised controlled study comparing healing outcomes. There were two cohorts: one treated with LAVIOR Diabetic Wound Gel (LDWG; Lavior Pharma Inc., US), which contains botanical extracts, and the other treated with SoloSite Wound Gel (SSWG) (Smith+Nephew Inc., US). The wounds were treated and evaluated weekly over a six-week period. Subjective patient data were collected with the Diabetic Foot Scale (DFS) at each visit.

Results: The study cohort comprised 65 patients: 34 patients treated with LDWG, and 31 patients treated with SSWG. The patients treated with LDWG demonstrated at least as much progress in healing as those treated with SSWG. There was a greater reduction in wound surface area in the LDWG group from baseline to the end of the study (7.32cm² to 2.24cm²) than in the SSWG group (8.18cm² to 5.16cm²) (p=0.127). Reduction in pain was significantly improved in wounds treated with LDWG compared with SSWG (during follow-up weeks 1-4; p<0.001; week 5 was not statistically significant). The LDWG group demonstrated significantly greater improvement in DFS scores by the end of the study (scores of 192 versus 219, respectively, compared with the SSWG group; p=0.001). Wound closure times were comparable between the two groups.

Conclusion: In this study, LDWG demonstrated non-inferiority to SSWG; better results were observed in pain reduction and surface area reduction. Further study is indicated.

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多模态植物水凝胶愈合伤口：临床结果比较研究。

目的：糖尿病足创伤在愈合过程中面临诸多挑战，往往成为难以愈合的（慢性）伤口。本研究将一种新型植物水凝胶与一种广泛使用的水凝胶进行比较，以确定其非劣效性及其对糖尿病足部伤口进展的影响。方法：该研究是一项前瞻性，双盲，随机对照研究，比较愈合结果。有两组：一组使用LAVIOR糖尿病伤口凝胶（LDWG）；Lavior Pharma Inc.，美国)，其中含有植物提取物，另一个用SoloSite伤口凝胶（SSWG）（Smith+Nephew Inc.，美国）治疗。在六周的时间里，每周对伤口进行治疗和评估。在每次就诊时使用糖尿病足量表（DFS）收集患者的主观数据。结果：本研究共纳入65例患者：LDWG治疗34例，SSWG治疗31例。LDWG治疗的患者在愈合方面的进展至少与SSWG治疗的患者一样多。从基线到研究结束，LDWG组创面面积的减少（7.32cm2至2.24cm2）比SSWG组（8.18cm2至5.16cm2）更大（p=0.127）。与SSWG相比，LDWG治疗的伤口疼痛减轻明显改善(随访1-4周；结论：在本研究中，LDWG对SSWG具有非劣效性；在疼痛减轻和表面面积减少方面观察到较好的效果。建议进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.