Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress.

IF 2.1 3区医学 Q3 UROLOGY & NEPHROLOGY

International Neurourology Journal Pub Date : 2025-06-01 Epub Date: 2025-06-30 DOI:10.5213/inj.2448460.230

Zhao Luo, Su Jin Kim, Jiangnan Xu, Chuan Lin, Yu Seob Shin

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引用次数: 0

Abstract

Purpose: The relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the association between elevated LAP indices and SUI in women, specifically examining the mediating effects of oxidative stress and inflammatory factors.

Methods: Data from 4,292 participants across 6 consecutive cycles of the National Health and Nutrition Examination Survey were analyzed. Logistic regression and subgroup analyses, adjusted for various covariates, were performed to investigate the relationship between LAP and the prevalence of SUI in adult women. Additionally, mediation analysis was conducted to evaluate the contributions of oxidative stress and inflammatory factors to this association.

Results: The prevalence of SUI among women in the United States was 46.02%. After adjustment for confounding factors, the odds ratio for LAP and SUI was 1.003 (95% confidence interval, 1.001-1.004; P=0.002), indicating a positive association. Gamma-glutamyl transferase mediated this relationship, explaining 40.0% of the effect (P=0.036).

Conclusion: This study's findings indicate a positive association between LAP and the prevalence of SUI in women, with oxidative stress potentially acting as a mediator in this relationship.

Abstract Image

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脂质积累产物与美国女性应激性尿失禁之间的关系：氧化应激的中介作用。

目的：脂质堆积产物（LAP）与女性应激性尿失禁（SUI）之间的关系尚不清楚，氧化应激和炎症因子在这一过程中的潜在介导作用尚未得到广泛研究。本分析旨在探讨LAP指数升高与女性SUI之间的关系，特别是检查氧化应激和炎症因子的介导作用。方法：对全国健康与营养调查连续6个周期的4292名参与者的数据进行分析。采用Logistic回归和亚组分析，对各种协变量进行校正，以调查LAP与成年女性SUI患病率之间的关系。此外，还进行了中介分析，以评估氧化应激和炎症因子对这种关联的贡献。结果：美国女性SUI患病率为46.02%。校正混杂因素后，LAP和SUI的优势比为1.003(95%可信区间为1.001 ~ 1.004；P=0.002)，表明两者呈正相关。γ -谷氨酰转移酶介导了这种关系，解释了40.0%的影响（P=0.036）。结论：本研究结果表明LAP与女性SUI患病率呈正相关，氧化应激可能在这种关系中起中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Neurourology Journal UROLOGY & NEPHROLOGY-

CiteScore

4.40

自引率

21.70%

发文量

审稿时长

4 weeks

期刊介绍： The International Neurourology Journal (Int Neurourol J, INJ) is a quarterly international journal that publishes high-quality research papers that provide the most significant and promising achievements in the fields of clinical neurourology and fundamental science. Specifically, fundamental science includes the most influential research papers from all fields of science and technology, revolutionizing what physicians and researchers practicing the art of neurourology worldwide know. Thus, we welcome valuable basic research articles to introduce cutting-edge translational research of fundamental sciences to clinical neurourology. In the editorials, urologists will present their perspectives on these articles. The original mission statement of the INJ was published on October 12, 1997. INJ provides authors a fast review of their work and makes a decision in an average of three to four weeks of receiving submissions. If accepted, articles are posted online in fully citable form. Supplementary issues will be published interim to quarterlies, as necessary, to fully allow berth to accept and publish relevant articles.