The variability of in vivo sunscreen sun protection factor values.

IF 2.7 4区医学 Q2 DERMATOLOGY

International Journal of Cosmetic Science Pub Date : 2025-07-10 DOI:10.1111/ics.70000

Curtis Cole, Bertrand Colson, Steffen Uhlig

引用次数: 0

Abstract

14 July 2025: This article was published in Early View in error. The article is meant for a special issue to be published shortly.

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体内防晒霜防晒因子值的可变性。

目的：测定一种防晒产品所提供的晒伤保护作用，这类产品的销售需要在全球范围内进行。在过去的80年里，确定防晒系数的许多方面都发生了变化和修改，对防晒系数（SPF）值的影响程度各不相同。为了比较新的非侵入性和体外方法与传统的SPF测试方案，进行了一项大型多中心临床试验，以确定这些新方法与现行编纂的测试标准ISO24444（[1]：化妆品-防晒方法-体内防晒系数（SPF）测定，2019）的等效水平。本报告报告了体内测定SPF值时发现的可变性。方法：对32种不同防晒水平和UVA防护水平的产品进行编码，并将其发送到具有预认证资格的体内SPF测试实验室，这些产品具有不同的配方载体和紫外线（UV）过滤器组合和浓度。产品分为8个产品组（每个产品组4个产品）。对于每个产品组，样品被送到四个实验室（跨产品组，共有12个实验室参与）。对每个产品组分别计算精度和正确率估计。未向测试实验室提供“预期”SPF值。然而，实验室被告知“真实”的SPF值是小于还是大于25。结果：样品的实验室间可变性与产品的SPF成正比，SPF高的产品具有更高的可变性。实验室内变异性（可重复性）远低于实验室间变异性。结论：本研究强调了一个事实，即SPF结果的实验室间差异相当大，可能比公众和监管机构预期的要大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Cosmetic Science DERMATOLOGY-

CiteScore

4.60

自引率

4.30%

发文量

期刊介绍： The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.