The role of innate immune system in respiratory viral infection related asthma.

IF 4.8 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-06-25 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1604831

Xiao Wu, Feifei Huang, Wenbo Yao, Zheng Xue

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引用次数: 0

Abstract

The association between viral infections and asthma has garnered significant attention in recent years. Accumulating evidence suggests that viral infections can trigger asthma exacerbations, while asthma may also influence the susceptibility to viral infections, thereby creating a cycle of worsening symptoms and recurrent asthma attacks. Given that asthma is predominantly driven by Type 2 immune responses and viral infections are typically associated with Type 1 immune responses, the innate immune cells and cytokines that participate in both conditions appear to be the critical bridge connecting these two processes. In particular, innate immune cells play a pivotal role in modulating the immune response at the interface of viral infections and asthma. In this review, we summarize the key innate immune cells and cytokines involved in viral infections and asthma, highlighting their immunoregulatory mechanisms. We aim to provide novel perspectives and potential therapeutic directions for the clinical management of recurrent asthma attacks induced by viral infections.

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先天免疫系统在呼吸道病毒感染相关哮喘中的作用。

近年来，病毒感染与哮喘之间的关系引起了人们的极大关注。越来越多的证据表明，病毒感染可引发哮喘恶化，而哮喘也可能影响对病毒感染的易感性，从而造成症状恶化和哮喘复发的循环。鉴于哮喘主要由2型免疫反应驱动，而病毒感染通常与1型免疫反应相关，参与这两种情况的先天免疫细胞和细胞因子似乎是连接这两个过程的关键桥梁。特别是，先天免疫细胞在调节病毒感染和哮喘界面的免疫反应中起着关键作用。本文综述了参与病毒感染和哮喘的主要先天免疫细胞和细胞因子，重点介绍了它们的免疫调节机制。我们旨在为病毒感染引起的哮喘复发的临床治疗提供新的视角和潜在的治疗方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.