{"title":"Design and Optimization of Refractive Index-based Spiral Shape Twin-core Photonic Crystal Fiber Sensor for Detection of Blood Components.","authors":"Shubham Sharma, Ajeet Kumar, Than Singh Saini","doi":"10.1007/s12013-025-01814-2","DOIUrl":null,"url":null,"abstract":"<p><p>In this article, we have proposed a sensor capable of sensing and detecting various blood constituents within the terahertz frequency range. Our model has been constructed using COMSOL Multiphysics software, and we have analyzed the optical properties using the full vectorial finite-element method (FV-FEM). A solid core is chosen for the proposed sensor due to its unique ability to transmit light across a wide range of wavelengths. Since blood is a critical fluid in the human body, the identification of its components holds significant importance. Our innovative design features a spiral-shaped twin-core photonic crystal fiber (SSTC-PCF) sensor that targets key blood components having different refractive indices (RI), including water, plasma, white blood cells (WBCs), hemoglobin, and red blood cells (RBCs). The cladding in spiral geometry enhances the modal confinement and offers enhanced birefringence to our structure. In the proposed PCF design, different blood components are introduced into the small central elliptical hole serving as the sensing channel. Further, the sensing capabilities have been assessed by evaluating the coupling length and analyzing the transmission power spectrum, which has been calculated using the effective mode indices of the coupling modes. The presented model is simulated in the terahertz range (0.7-0.8 THz) to calculate optical properties. The proposed sensor is designed to work within a refractive index range of 1.33-1.40, allowing for effective detection of key blood components. The proposed SSTC-PCF sensor exhibits the highest sensitivity achieved at 5,75,511 nm/RIU with less coupling length and better than published previous works, which is the main feature of the proposed sensor. Additionally, maximum birefringence values for x-polarization are 3.27 × 10<sup>-3</sup>, 3.67 × 10<sup>-3</sup>, 3.90 × 10<sup>-3</sup>, 4.44 × 10<sup>-3</sup> and 5.14 × 10<sup>-3</sup> for water, plasma, WBC, Hemoglobin, and RBC, respectively, and the highest coupling length values for x-polarization are 0.09 m for water, 0.08 m for plasma, 0.08 m for WBCs, 0.07 m for hemoglobin, and 0.06 m for RBC. This sensor design offers high sensitivity and a short coupling length, making it suitable for various applications in the biomedical field.</p>","PeriodicalId":510,"journal":{"name":"Cell Biochemistry and Biophysics","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12013-025-01814-2","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In this article, we have proposed a sensor capable of sensing and detecting various blood constituents within the terahertz frequency range. Our model has been constructed using COMSOL Multiphysics software, and we have analyzed the optical properties using the full vectorial finite-element method (FV-FEM). A solid core is chosen for the proposed sensor due to its unique ability to transmit light across a wide range of wavelengths. Since blood is a critical fluid in the human body, the identification of its components holds significant importance. Our innovative design features a spiral-shaped twin-core photonic crystal fiber (SSTC-PCF) sensor that targets key blood components having different refractive indices (RI), including water, plasma, white blood cells (WBCs), hemoglobin, and red blood cells (RBCs). The cladding in spiral geometry enhances the modal confinement and offers enhanced birefringence to our structure. In the proposed PCF design, different blood components are introduced into the small central elliptical hole serving as the sensing channel. Further, the sensing capabilities have been assessed by evaluating the coupling length and analyzing the transmission power spectrum, which has been calculated using the effective mode indices of the coupling modes. The presented model is simulated in the terahertz range (0.7-0.8 THz) to calculate optical properties. The proposed sensor is designed to work within a refractive index range of 1.33-1.40, allowing for effective detection of key blood components. The proposed SSTC-PCF sensor exhibits the highest sensitivity achieved at 5,75,511 nm/RIU with less coupling length and better than published previous works, which is the main feature of the proposed sensor. Additionally, maximum birefringence values for x-polarization are 3.27 × 10-3, 3.67 × 10-3, 3.90 × 10-3, 4.44 × 10-3 and 5.14 × 10-3 for water, plasma, WBC, Hemoglobin, and RBC, respectively, and the highest coupling length values for x-polarization are 0.09 m for water, 0.08 m for plasma, 0.08 m for WBCs, 0.07 m for hemoglobin, and 0.06 m for RBC. This sensor design offers high sensitivity and a short coupling length, making it suitable for various applications in the biomedical field.
期刊介绍:
Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems
The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized.
Examples of subject areas that CBB publishes are:
· biochemical and biophysical aspects of cell structure and function;
· interactions of cells and their molecular/macromolecular constituents;
· innovative developments in genetic and biomolecular engineering;
· computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies;
· photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design
For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.