{"title":"Cover Feature: An Alternative Mechanistic Paradigm for the Electrochemical C-Terminal Decarboxylation of Peptides (ChemElectroChem 14/2025)","authors":"Adam J. Sowers, Kevin D. Moeller, Kim S. Halskov","doi":"10.1002/celc.70019","DOIUrl":null,"url":null,"abstract":"<p><b>A molecular binding event</b> achieves a selective oxidation of C-terminal peptide acids in the presence of the electron-rich tyrosine residue. Much like a puzzle, the iron mediator easily fits to the C-terminal dicarboxylate, which behaves as a bidentate chelator for the metal center. Then, a two-electron oxidation, coupled with a rapid decarboxylation, leads to an iminium intermediate. More information can be found in the Research Article by Kevin D. Moeller, Kim S. Halskov, and Adam J. Sowers (10.1002/celc.202500142).\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":142,"journal":{"name":"ChemElectroChem","volume":"12 14","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/celc.70019","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemElectroChem","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/celc.70019","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ELECTROCHEMISTRY","Score":null,"Total":0}
引用次数: 0
Abstract
A molecular binding event achieves a selective oxidation of C-terminal peptide acids in the presence of the electron-rich tyrosine residue. Much like a puzzle, the iron mediator easily fits to the C-terminal dicarboxylate, which behaves as a bidentate chelator for the metal center. Then, a two-electron oxidation, coupled with a rapid decarboxylation, leads to an iminium intermediate. More information can be found in the Research Article by Kevin D. Moeller, Kim S. Halskov, and Adam J. Sowers (10.1002/celc.202500142).
在富含电子的酪氨酸残基存在的情况下,分子结合事件实现了c端肽酸的选择性氧化。很像一个谜题,铁介质很容易与c端二羧酸盐结合,它作为金属中心的双齿螯合剂。然后,一个双电子氧化,加上一个快速脱羧,得到一个含铝中间体。更多信息可以在Kevin D. Moeller, Kim S. Halskov和Adam J. Sowers的研究文章(10.1002/celc.202500142)中找到。
期刊介绍:
ChemElectroChem is aimed to become a top-ranking electrochemistry journal for primary research papers and critical secondary information from authors across the world. The journal covers the entire scope of pure and applied electrochemistry, the latter encompassing (among others) energy applications, electrochemistry at interfaces (including surfaces), photoelectrochemistry and bioelectrochemistry.