Fasting Gastric Juice Melatonin Levels in Relation to Gastroduodenal Pathologies Among Zambian Patients: A Cross Sectional Study

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-07-10 DOI:10.1002/hsr2.71053

Jonathan Sibande, Mutinta Nyama Hankolwe, Paul Kelly, Violet Kayamba

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Abstract

Background and Aims

Melatonin is a hormone released from the pineal gland and enterochromaffin cells of the gastrointestinal tract. The influence of melatonin on gastric pathologies is not fully investigated. Our aim was to evaluate the relationship between fasting gastric juice melatonin levels and gastroduodenal pathologies among Zambian patients.

Methods

This cross-sectional study was conducted in Lusaka, Zambia. We collected morning fasting gastric juice samples from patients presenting for oesophagogastroduodenoscopy (OGD) to quantify levels of melatonin using commercial ELISA kits. Interviewer administered questionnaires were used to collect baseline characteristics. Data were analyzed in Stata version 15.

Results

We collected gastric juice from 175 patients with a median age of 49 years, IQR (40–65). The number of females was 95 (54%) and males 80 (46%). Of these, 100 (57%) had normal OGD examinations, 49 (28%) peptic ulcers, 25 (14%) gastric cancer and 1 (1%) gastric polyp. The median level of melatonin in normal patients was 141.8 pg/mL, IQR (46.2–500.1). In those with gastroduodenal pathologies, the median was 339.4 pg/mL, IQR (101.8–500.1) and the difference was statistically significant, p = 0.02. Results also revealed significantly higher levels of melatonin among patients with history of cigarette smoking, p = 0.003.

Conclusion

There is an association between gastroduodenal pathology and morning gastric juice melatonin levels, a finding whose biological significance warrants further research.

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赞比亚患者空腹胃液褪黑素水平与胃十二指肠病理的关系：一项横断面研究

背景与目的褪黑素是一种由胃肠道松果体和肠色素细胞释放的激素。褪黑素对胃病理的影响尚未得到充分研究。我们的目的是评估赞比亚患者空腹胃液褪黑素水平与胃十二指肠病变之间的关系。方法本横断面研究在赞比亚卢萨卡进行。我们收集了接受食管胃十二指肠镜检查（OGD）的患者的晨禁食胃液样本，使用商用ELISA试剂盒量化褪黑激素的水平。采用采访者管理的问卷收集基线特征。在Stata version 15中分析数据。结果我们收集了175例患者的胃液，中位年龄49岁，IQR（40-65岁）。女性95人（54%），男性80人（46%）。其中100例（57%）OGD检查正常，49例（28%）消化性溃疡，25例（14%）胃癌，1例（1%）胃息肉。正常患者褪黑素的中位水平为141.8 pg/mL， IQR（46.2-500.1）。胃十二指肠病变组中位值为339.4 pg/mL， IQR(101.8 ~ 500.1)，差异有统计学意义，p = 0.02。结果还显示，有吸烟史的患者的褪黑激素水平明显较高，p = 0.003。结论胃十二指肠病理与晨起胃液褪黑素水平相关，其生物学意义值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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