{"title":"Microscopic Polyangiitis With a Twist: A Rare Case of CRAO and Brainstem Infarction","authors":"Govind Singh Mann, Saurabh Nandwani, Nitin Jain","doi":"10.1016/j.jneuroim.2025.578685","DOIUrl":null,"url":null,"abstract":"<div><div>Microscopic polyangiitis (MPA) is a rare autoimmune vasculitis of small vessels. It is often linked with ANCA. Central retinal artery occlusion (CRAO) is characterized by sudden, painless vision loss and is typically connected with embolic or inflammatory causes. However, limited literature exists on its association with MPA. This case report uniquely highlights a 50 year old patient diagnosed with MPA exhibiting CRAO and brainstem infarct. The report stresses the importance of early recognition of uncommon vascular manifestations, multidisciplinary diagnostic approaches, and the integration of immunosuppressive therapies for optimal management of systemic vasculitis.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"406 ","pages":"Article 578685"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neuroimmunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165572825001663","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Microscopic polyangiitis (MPA) is a rare autoimmune vasculitis of small vessels. It is often linked with ANCA. Central retinal artery occlusion (CRAO) is characterized by sudden, painless vision loss and is typically connected with embolic or inflammatory causes. However, limited literature exists on its association with MPA. This case report uniquely highlights a 50 year old patient diagnosed with MPA exhibiting CRAO and brainstem infarct. The report stresses the importance of early recognition of uncommon vascular manifestations, multidisciplinary diagnostic approaches, and the integration of immunosuppressive therapies for optimal management of systemic vasculitis.
期刊介绍:
The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.