Effects of europinidin-o-methylated anthocyanidin on scopolamine-induced memory impairments by improving neurological expression: An integrated with insilico and ADMET properties by computational analysis

IF 1.7 4区心理学 Q3 PSYCHOLOGY, BIOLOGICAL

Learning and Motivation Pub Date : 2025-07-11 DOI:10.1016/j.lmot.2025.102161

Mohamamd Anas Ansari , Faisal Imam , Naif O. Al-Harbi , Emine Guven , Md Sohrab Alam , Md Maaz Ahmad , Shoaeb Mohammad Syed , Meraj Khan , Nadeem Sayyed

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引用次数: 0

Abstract

This research aimed to determine if europinidin-o-methylated anthocyanidin could protect rats from memory and learning impairments induced by scopolamine (SCOP). The experiment involved four groups of Wistar rats with normal control, SCOP-treated group, europinidin (10 mg/kg and 20 mg/kg p.o.) for 14-day. After that, assessments of movement, memory recall, and learning were conducted. Brain tissue was analyzed for various markers, namely choline acetyltransferase (ChAT), acetylcholine esterase (AChE), antioxidants, nitrites, anti-inflammatory, and brain-derived neurotrophic factor (BDNF). SCOP significantly impaired memory and altered brain chemistry. Europinidin treatment, however, reversed these effects, improving neurobehavioral function, reducing oxidative stress and inflammation, and restoring AChE, ChAT, and BDNF levels. Docking studies further revealed europinidin's favourable interaction with ChAT, supporting its protective mechanism. Europinidin showed favorable affinity towards ChAT with docking scores of -8.77 kcal/mol. The study demonstrates europinidin effectiveness in mitigating SCOP-induced memory deficits among rats.

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europinidin-o-甲基化花青素通过改善神经表达对东莨菪碱诱导的记忆障碍的影响：通过计算分析集成了insilico和ADMET特性

本研究旨在探讨欧花青素甲基化花青素是否能保护大鼠免受东莨菪碱（SCOP）所致的记忆和学习障碍。Wistar大鼠分为正常对照组、scopo处理组、europinidin(10 mg/kg和20 mg/kg p.o) 4组，试验期为14 d。之后，对运动、记忆回忆和学习进行评估。分析脑组织的各种标志物，即胆碱乙酰转移酶（ChAT）、乙酰胆碱酯酶（AChE）、抗氧化剂、亚硝酸盐、抗炎剂和脑源性神经营养因子（BDNF）。SCOP显著损害记忆和改变脑化学。然而，Europinidin治疗逆转了这些作用，改善了神经行为功能，减少了氧化应激和炎症，恢复了AChE、ChAT和BDNF水平。对接研究进一步揭示了europinidin与ChAT的良好相互作用，支持其保护机制。Europinidin对ChAT具有良好的亲和性，对接分数为-8.77 kcal/mol。本研究证实了欧匹尼定对大鼠scope -induced memory deficits的缓解效果。

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来源期刊

Learning and Motivation Multiple-

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Learning and Motivation features original experimental research devoted to the analysis of basic phenomena and mechanisms of learning, memory, and motivation. These studies, involving either animal or human subjects, examine behavioral, biological, and evolutionary influences on the learning and motivation processes, and often report on an integrated series of experiments that advance knowledge in this field. Theoretical papers and shorter reports are also considered.