Call for action: Adverse drug events and level of harm in hospitalized pediatric patients in Palestine: A retrospective cohort study

Abstract

Background

Adverse drug events (ADEs) are a significant cause of preventable harm among hospitalized pediatric patients. However, data on ADEs in Palestine remain limited.

Objective

This study aimed to determine the incidence, types, and severity of ADEs among hospitalized children in Palestine and to identify associated risk factors.

Methods

A retrospective cohort study was conducted across six hospitals in the West Bank. Medical records of 600 pediatric inpatients (aged <15 years) hospitalized for at least 48 h were reviewed using the Institute for Healthcare Improvement (IHI) Global Trigger Tool (GTT) adapted for pediatrics. ADEs were identified and categorized by severity using the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) Index, and they were analyzed in relation to patient demographics and hospital characteristics.

Results

A total of 155 ADEs were detected, with an overall incidence of 65.2 per 1000 patient-days and 67.0 per 1000 medication doses. The most common triggers were rash, anti-allergic medication use, and abrupt cessation of medication. Most ADEs (72.3 %) caused temporary harm requiring intervention (Category E), while 25.6 % resulted in prolonged hospitalization (Category F). Risk factors significantly associated with ADE occurrence included older age, private hospital admission, longer hospital stay, and regional differences.

Conclusions

The incidence of ADEs in Palestinian pediatric inpatients is higher than previously reported internationally, underscoring the need to enhanced patient safety measures. Implementing standardized monitoring tools like the GTT can support early ADE detection and improve the quality of pediatric care.