Studying ovarian aging and its health impacts: modern tools and approaches

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-07-10 DOI:10.1101/gad.352732.125

Bérénice A. Benayoun, Alison Kochersberger, Jennifer L. Garrison

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引用次数: 0

Abstract

Ovarian aging is a critical yet understudied driver of systemic aging in female bodies, with profound implications for female health and longevity. Despite its significance, we still know little about ovarian aging and its systemic effects on aging trajectories. With new efforts over the past few years, interest in the field has been growing and there is momentum to address these questions. This review highlights the importance of leveraging modern tools and approaches to better understand ovarian aging and its impact on health span. Specifically, we believe it will be useful for both aging researchers looking to go into research on ovarian aging and reproductive researchers looking to adopt more modern toolkit. We focus on menopause—a key marker of ovarian aging—as a lens through which to examine the current state of the field, identify limitations in existing research, and outline goals for future progress. By emphasizing cutting-edge techniques and emerging models, we seek to illuminate new pathways for research that could lead to improved strategies for managing ovarian aging and enhancing overall female health.

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研究卵巢老化及其对健康的影响：现代工具和方法

卵巢衰老是女性身体系统性衰老的一个关键因素，但尚未得到充分研究，对女性健康和长寿有着深远的影响。尽管其意义重大，但我们对卵巢衰老及其对衰老轨迹的系统性影响知之甚少。随着过去几年的新努力，人们对该领域的兴趣不断增长，并且有了解决这些问题的势头。这篇综述强调了利用现代工具和方法来更好地了解卵巢衰老及其对健康跨度的影响的重要性。具体地说，我们相信这将是有用的老龄化研究人员希望进入卵巢老化的研究和生殖研究人员希望采用更现代的工具包。我们将重点放在更年期——卵巢衰老的一个关键标志——作为一个透镜，通过它来检查该领域的现状，确定现有研究的局限性，并概述未来进展的目标。通过强调尖端技术和新兴模型，我们寻求阐明新的研究途径，从而改善管理卵巢衰老和增强整体女性健康的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).