Factors associated with persistent blood stream infection in the Neonatal Intensive Care Unit.

Research square Pub Date : 2025-07-01 DOI:10.21203/rs.3.rs-6946297/v1

Hanna Lee, Noa Fleiss, Matthew Bizzarro, Richard Feinn, Michelle Rychalsky, Christine Puthawala, David R Peaper, Thomas S Murray

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Abstract

Objective: This study determined factors associated with persistent blood stream infections (BSIs) for infants in the NICU to identify when follow up blood cultures (FUBCs) have increased utility.

Study design: Single center study of all infants in a level IV NICU (n=121) with a positive blood culture over a five-year period. Clinical and microbiological variables were examined with bivariate and multi-regression analyses to identify factors associated with persistent BSI, defined as growth of the same organism >48 hours after the index culture.

Results: The recovery of Staphylococcus aureus (OR=6.10, p<.001), male sex (OR=3.31, p=.020), the presence of a central venous catheter (OR=3.73, p=.020), and BSI in the setting of late-onset sepsis (p<.001) were associated with persistent BSI. No infants with either early-onset sepsis or growth of Streptococcal sp. had a persistent BSI.

Conclusion: In the NICU, both patient and microbial characteristics can inform diagnostic stewardship regarding the need for FUBCs.

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新生儿重症监护病房持续血流感染的相关因素

目的：本研究确定了新生儿重症监护病房（NICU）婴儿持续性血流感染（bsi）的相关因素，以确定随访血培养（fubc）何时具有更大的效用。研究设计：单中心研究，纳入5年期间血培养阳性的所有IV级NICU婴儿（n=121）。临床和微生物变量通过双变量和多元回归分析来确定与持续性BSI相关的因素，定义为在指数培养后48小时同一生物体的生长。结果：金黄色葡萄球菌的回收率（OR=6.10, p）结论：在新生儿重症监护病房，患者和微生物特征都可以为诊断管理人员提供关于是否需要fubc的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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