Providing Standardized Gene Nomenclature for Domestic Ungulate Scavenger Receptor Genes.

Abstract

Scavenger Receptor (SCAR) genes are a heterogeneous group involved in innate immunity and immunomodulation. While standardized gene nomenclature is provided for model organism SCAR genes, ungulates have novel SCAR genes which have not been systematically classified. This study compares SCAR genes for five representative ungulate species which are selected based on their agricultural importance and representation. We identify and classify twenty-seven SCAR genes common to all species and provide standardized gene nomenclature for genes novel to these ungulate species. Notably, we provide standardized gene nomenclature for the previously studied Workshop Cluster 1 (WC1) genes which are absent in model organisms.