Discordance of Small Dense LDL Cholesterol Beyond LDL Cholesterol or Non-HDL Cholesterol and Carotid Plaque.

Jinqi Wang, Xiaoyu Zhao, Yanchen Zhao, Rui Jin, Yunfei Li, Jiahe Wang, Yueruijing Liu, Zhiyuan Wu, Xiuhua Guo, Lixin Tao
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引用次数: 0

Abstract

Background: Different low-density lipoprotein (LDL) particles exhibit distinct proatherogenic properties.

Objectives: This study sought to evaluate associations of small dense low-density lipoprotein cholesterol (sdLDL-C), large buoyant low-density lipoprotein cholesterol (lbLDL-C), sdLDL-C/LDL-C ratio, and sdLDL-C/lbLDL-C ratio with carotid plaque (CP) risk in the general population, and to perform discordance analyses to determine which biomarker better reflects CP risk beyond low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C).

Methods: This study enrolled 20,369 participants from Beijing Health Management Cohort. Discordant sdLDL-C, lbLDL-C, or ratio metrics (sdLDL-C/LDL-C and sdLDL-C/lbLDL-C) relative to LDL-C or non-HDL-C, and discordant ratio metrics relative to sdLDL-C, were defined by residual differences and median values. Logistic regression models were used to estimate ORs and 95% CIs.

Results: In this study, higher levels of sdLDL-C (OR: 1.354; 95% CI: 1.299-1.410), sdLDL-C/LDL-C ratio (OR: 1.196; 95% CI: 1.148-1.247), and sdLDL-C/lbLDL-C ratio (OR: 1.153; 95% CI: 1.110-1.197) were more strongly associated with increased odds of CP than lbLDL-C (OR: 1.110; 95% CI: 1.070-1.151). Additionally, discordantly high sdLDL-C or low lbLDL-C relative to LDL-C or non-HDL-C were associated with increased odds of CP, whereas discordantly low sdLDL-C or high lbLDL-C were associated with reduced odds. Finally, discordantly high sdLDL-C/LDL-C and sdLDL-C/lbLDL-C ratios relative to LDL-C, non-HDL-C, or sdLDL-C were linked to increased odds of CP.

Conclusions: The sdLDL-C, sdLDL-C/LDL-C, and sdLDL-C/lbLDL-C, but not lbLDL-C, are superior to LDL-C and non-HDL-C in identifying individuals at increased risk of CP. The sdLDL-C/LDL-C and sdLDL-C/lbLDL-C ratios may capture additional risk information beyond sdLDL-C.

小密度低密度脂蛋白胆固醇高于低密度脂蛋白胆固醇或非高密度脂蛋白胆固醇与颈动脉斑块的不一致
背景:不同的低密度脂蛋白(LDL)颗粒表现出不同的致动脉粥样硬化特性。目的:本研究旨在评估普通人群中小密度低密度脂蛋白胆固醇(sdLDL-C)、大密度低密度脂蛋白胆固醇(lbLDL-C)、sdLDL-C/LDL-C比率和sdLDL-C/lbLDL-C比率与颈动脉斑块(CP)风险的关系,并进行不一致分析,以确定哪种生物标志物比低密度脂蛋白胆固醇(LDL-C)和非高密度脂蛋白胆固醇(non-HDL-C)更能反映CP风险。方法:本研究从北京健康管理队列中招募了20,369名参与者。相对于LDL-C或非hdl - c的不一致的sdLDL-C、lbLDL-C或比值指标(sdLDL-C/LDL-C和sdLDL-C/lbLDL-C),以及相对于sdLDL-C的不一致的比值指标,由残差和中位数来定义。Logistic回归模型用于估计or和95% ci。结果:在本研究中,较高水平的sdLDL-C (OR: 1.354;95% CI: 1.299-1.410), sdLDL-C/LDL-C比值(OR: 1.196;95% CI: 1.148-1.247)和sdLDL-C/lbLDL-C比值(OR: 1.153;95% CI: 1.110-1.197)比lbLDL-C与CP几率增加的相关性更强(OR: 1.110;95% ci: 1.070-1.151)。此外,相对于LDL-C或非hdl - c而言,不一致的高sdLDL-C或低lbLDL-C与CP的患病几率增加有关,而不一致的低sdLDL-C或高lbLDL-C与患病几率降低有关。最后,与LDL-C、非hdl - c或sdLDL-C相比,不一致的高sdLDL-C/LDL-C和sdLDL-C/lbLDL-C与CP风险增加有关。结论:在识别CP风险增加个体方面,sdLDL-C、sdLDL-C/LDL-C和sdLDL-C/lbLDL-C优于LDL-C和非hdl - c,但不是lbLDL-C。sdLDL-C/LDL-C和sdLDL-C/lbLDL-C比值可以捕获sdLDL-C之外的其他风险信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JACC. Asia
JACC. Asia Cardiology and Cardiovascular Medicine
CiteScore
4.00
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