Uric Acid in First-Episode Psychosis: A Systematic Review.

IF 3.5 Q3 PSYCHIATRY

Alpha psychiatry Pub Date : 2025-06-25 eCollection Date: 2025-06-01 DOI:10.31083/AP44248

Daniel Rego, Sofia Ramos Ferreira, Nuno Madeira

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Abstract

Background: Psychotic disorders such as schizophrenia (SCZ) have been frequently linked with oxidative stress, with uric acid (UA) levels being of particular interest, although evidence remains inconclusive. A possible reduction of UA levels in early phases of SCZ, namely first-episode psychosis (FEP), has been hypothesized. In this systematic review, we aimed to analyze and summarize current evidence regarding UA levels in patients with early psychosis.

Methods: We conducted a systematic review of case-control studies comparing serum or plasma UA levels in individuals experiencing FEP with those in healthy controls (HC).

Results: Eight studies met the inclusion criteria, with a total sample of 950 individuals that included 520 FEP patients and 430 HC. A tendency for lower UA levels in FEP was described, albeit without definitive evidence, and decreased UA levels were restricted to certain ethnic populations.

Conclusions: Our findings do not fully support the hypothesis of an oxidative stress response in early psychosis translatable with reduced UA levels in patients with FEP. Further research is warranted to elucidate the nature and magnitude of the relationship between oxidative stress, UA levels, and early psychosis.

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尿酸与首发精神病：一项系统综述。

背景：精神障碍如精神分裂症（SCZ）经常与氧化应激有关，尿酸（UA）水平尤其令人感兴趣，尽管证据仍不确定。在SCZ的早期阶段，即首发精神病（FEP），可能存在UA水平降低的假设。在这篇系统综述中，我们旨在分析和总结有关早期精神病患者UA水平的现有证据。方法：我们对病例对照研究进行了系统回顾，比较FEP患者与健康对照组（HC）的血清或血浆UA水平。结果：8项研究符合纳入标准，总样本为950人，其中包括520例FEP患者和430例HC患者。尽管没有明确的证据，但研究人员描述了FEP患者UA水平较低的趋势，并且UA水平下降仅限于某些种族人群。结论：我们的研究结果并不完全支持FEP患者早期精神病的氧化应激反应与UA水平降低的假设。需要进一步的研究来阐明氧化应激、UA水平和早期精神病之间关系的性质和程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alpha psychiatry

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