Katherine R Long, Wieland B Huttner, Takashi Namba
{"title":"Neocortex folding in primates up to human - evolution and mechanisms.","authors":"Katherine R Long, Wieland B Huttner, Takashi Namba","doi":"10.1159/000547228","DOIUrl":null,"url":null,"abstract":"<p><p>Folding of the neocortex is a fundamental feature of brain development in many mammalian species, notably in most non-human primates and in particular in human. Cortical folding is thought to allow fitting a larger cortical surface area, with a greater number of neurons, into the limited size of the cranial cavity. Here, we review the following key topics related to cortical folding. We first discuss principles of cortical folding and dissect the factors contributing to the mechanical asymmetry that is thought to have a key role in folding. We then address the evolution of cortical folding and discuss the two principal types of folding, the conserved folding and the evolved folding, and the roles of neuron production vs. neuron migration in these two types. We then sequentially review human models, animal models and computational models of cortical folding. This includes a discussion of human malformations of cortical folding, the potential of cerebral organoids to study folding, the power of the ferret model to dissect mechanisms of cortical folding, and the use of computational models to make predictions about cortical folding. Finally, we address future perspectives of folding research and outline directions that research may take.</p>","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"1-21"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000547228","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Folding of the neocortex is a fundamental feature of brain development in many mammalian species, notably in most non-human primates and in particular in human. Cortical folding is thought to allow fitting a larger cortical surface area, with a greater number of neurons, into the limited size of the cranial cavity. Here, we review the following key topics related to cortical folding. We first discuss principles of cortical folding and dissect the factors contributing to the mechanical asymmetry that is thought to have a key role in folding. We then address the evolution of cortical folding and discuss the two principal types of folding, the conserved folding and the evolved folding, and the roles of neuron production vs. neuron migration in these two types. We then sequentially review human models, animal models and computational models of cortical folding. This includes a discussion of human malformations of cortical folding, the potential of cerebral organoids to study folding, the power of the ferret model to dissect mechanisms of cortical folding, and the use of computational models to make predictions about cortical folding. Finally, we address future perspectives of folding research and outline directions that research may take.
期刊介绍:
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.