Prevalence and determinants of hearing loss in systemic lupus erythematosus: A cross-sectional study in a tertiary care center in Saudi Arabia.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Medical Journal Pub Date : 2025-07-01 DOI:10.15537/smj.2025.46.7.20241075

Redha A Alrumaih, Amal A Alshaik, Manal A Hasan, Layan B Almulla, Sarah I Alsamin, Jood K Alotaibi, Batool A Alattas, Lojain M Maawadh

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Abstract

Objectives: To determine the prevalence of hearing loss in patients with systemic lupus erythematosus (SLE) and identify predictive factors associated with its development.

Methods: A cross-sectional study was conducted at the Rheumatology Clinic of King Fahad Hospital of the University, Al-Khobar, Saudi Arabia, between November 2023 and March 2024، involving patients diagnosed with SLE. Demographic data, clinical presentation, laboratory results, and medication history were collected. Pure-tone audiometry, speech audiometry, and tympanometry were used to assess hearing.

Results: Fifty-three patients with SLE were included. The prevalence of hearing loss was 15%, with 87.5% of cases being sensorineural hearing loss (SNHL). Logistic regression analysis showed that age over 36 years (p=0.020), diabetes mellitus (p=0.039), positive antinuclear antibody (ANA) (p=0.039), cranial nerve disorder (p=0.009), pyuria (p=0.012), and use of hydroxychloroquine (HCQ) (p=0.007) were significantly associated with an increased risk of hearing loss.

Conclusion: Hearing loss, particularly SNHL, was observed in SLE patients. Factors such as older age, diabetes mellitus, cranial nerve disorders, pyuria, positive ANA test results, and HCQ use may predict hearing loss. Regular audiological assessments are essential to mitigate this risk.

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系统性红斑狼疮听力损失的患病率和决定因素：沙特阿拉伯三级保健中心的横断面研究。

目的：确定系统性红斑狼疮（SLE）患者听力损失的患病率，并确定与其发展相关的预测因素。方法：一项横断面研究于2023年11月至2024年3月在沙特阿拉伯Al-Khobar大学法赫德国王医院风湿病学诊所进行，涉及诊断为SLE的患者。收集人口统计资料、临床表现、实验室结果和用药史。使用纯音测听、语音测听和鼓室测听来评估听力。结果：纳入53例SLE患者。听力损失患病率为15%，其中感音神经性听力损失（SNHL）占87.5%。Logistic回归分析显示，年龄超过36岁（p=0.020）、糖尿病（p=0.039）、抗核抗体（ANA）阳性（p=0.039）、脑神经障碍（p=0.009）、脓尿（p=0.012）、羟氯喹（HCQ）使用（p=0.007）与听力损失风险增加显著相关。结论：SLE患者存在听力损失，尤其是SNHL。年龄较大、糖尿病、脑神经疾病、脓尿、ANA测试结果阳性和使用HCQ等因素可能预测听力损失。定期听力学评估对于降低这种风险至关重要。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.