Brain-gut co-management: probiotic LAB improves mental health and further reduces disease activity in ulcerative colitis patients with emotional disturbance.
Xiaoning Liu, He Zhou, Jiaqi Zhang, Ruixia Li, Jie Liang
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引用次数: 0
Abstract
Objectives: Patients with Ulcerative Colitis (UC) are susceptible to emotional disturbance, which could negatively affect the condition itself. Meanwhile, certain probiotics have been proven to alleviate emotional disturbance, and improve disease status in UC. Yet little is known about probiotic's efficacy on UC patients with emotional disturbance.
Methods: Sixty patients were recruited, diagnosed as having mild to moderate UC and with anxiety and/or depression disorders. Participants were then randomly assigned to a control group receiving conventional treatment (mesalazine ≤4 g) or a probiotic group receiving probiotic LAB combined with conventional treatment for 8 weeks. At the commencement and conclusion of the study, questionnaires were administered to determine patients' improvements in emotional disturbance and disease activity. Stool samples were collected concurrently to estimate alterations in fecal microbiota.
Results: At 8 weeks, 65.4% of patients in the probiotic group had relieved anxiety disorder, compared to 34.6% in the control group (p = 0.03). Improvement on depression was higher in the probiotic group (53.8%) than the control group (30.8%), though without significant differences (p = 0.09). Both groups had reduced Modified Mayo Scores (MMS). Mayo Endoscopic Sub-score (MES) dropped significantly in the probiotic group (p = 0.02) but not in the control group. Fecal samples sequenced by 16S rRNA showed a significant increase in Firmicutes after receiving probiotics, and no significant differences were detected in the control group.
Discussion: This randomized trial demonstrated that supplementation with probiotic LAB could restore the abundance of Firmicutes, improve anxiety disorder, and reduce MES in UC patients with emotional disturbance.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT04006977, date October 2019.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
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