Adam Astrada, Gojiro Nakagami, Kosuke Kashiwabara, Hiromi Sanada
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引用次数: 0
Abstract
Objective: This study aimed to investigate the effectiveness of wound blotting-guided biofilm management in diabetic foot ulcers (DFUs) and to compare it to standard of care (SoC).
Method: This double-blinded, randomised controlled trial was conducted at an outpatient clinic in Pontianak City, Indonesia in September-November 2017 and June 2018-November 2019. Adults with diabetes with at least a two-week DFU located below the knee were included. Patients in the control group received SoC followed by the application of any appropriate dressings. Patients in the intervention group in addition to SoC also received additional wound cleansing according to the wound blotting result and antimicrobial dressing. Wound treatment was performed weekly for three weeks. Primary and secondary objectives were: the reductions in total depth; maceration; inflammation/infection; size; tissue type; type of wound edge; tunnelling/undermining (DMIST) score; and percentage of biofilm removal.
Results: A total of 162 participants were recruited. There were significant differences in the total DMIST score at week 3 (p<0.01) between groups and biofilm percentage reduction at week 1 (p=0.01) and week 2 (p=0.03).
Conclusion: The findings of this RCT showed that the intervention could significantly improve DFU healing and maximise biofilm elimination, especially after two weeks of treatment. A further study with a longer period of intervention, such as 12 weeks, is suggested to further evaluate the effectiveness of this intervention.
期刊介绍：
Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice.
In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers.
Specifically, JWC publishes:
High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more
The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide
In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments
Clinical case studies providing information on how to deal with complex wounds
Comprehensive literature reviews on current concepts and practice, including cost-effectiveness
Updates on the activities of wound care societies around the world.
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