Chitosan-based formulations for therapeutic applications. A recent overview.

IF 9 2区医学 Q1 CELL BIOLOGY

Journal of Biomedical Science Pub Date : 2025-07-08 DOI:10.1186/s12929-025-01161-7

Weronika Gonciarz, Ewa Balcerczak, Marek Brzeziński, Agnieszka Jeleń, Agnieszka J Pietrzyk-Brzezińska, Vedha Hari B Narayanan, Magdalena Chmiela

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引用次数: 0

Abstract

Chitosan is a cationic natural polymer composed of glucosamine and N-acetylglucosamine residues that are held together by a glycosidic bond. Chitosan has many excellent properties, including physicochemical properties, i.e., stability in the natural environment, chelation of metal ions, high sorption properties, biological properties such as biocompatibility and biological activity, ecological properties resulting from biodegradability, and physiological properties, which include non-toxicity, and economic affordability, and is used in various biomedical and industrial applications. The presented article highlights recent developments in chitosan-based formulations for the treatment of bacteria, viruses, cancer, or gastroesophageal reflux disease. Moreover, chitosan-derived biomaterials can also be used in regenerative medicine or food packaging to prevent contamination by pathogenic microorganisms. In summary, this is a valuable compilation in this emerging field that focuses on the biomedical application of chitosan-based biomaterials.

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基于壳聚糖的治疗应用配方。最近的概述。

壳聚糖是一种阳离子天然聚合物，由氨基葡萄糖和n -乙酰氨基葡萄糖残基通过糖苷键结合在一起。壳聚糖具有许多优异的性能，包括物理化学性能，如在自然环境中的稳定性、金属离子的螯合性、高吸附性、生物相容性和生物活性等生物学性能、生物降解性带来的生态性能以及无毒性和经济可承受性等生理性能，在生物医学和工业领域有着广泛的应用。提出的文章强调最近的发展，以壳聚糖为基础的配方治疗细菌，病毒，癌症，或胃食管反流病。此外，壳聚糖衍生的生物材料还可用于再生医学或食品包装，以防止病原微生物的污染。总之，这是一个有价值的汇编在这一新兴领域的重点是壳聚糖基生物材料的生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Science 医学-医学：研究与实验

CiteScore

18.50

自引率

0.90%

发文量

审稿时长

1 months

期刊介绍： The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.