Associations between commuting modes and risk of 16 site-specific cancers in the UK Biobank.

IF 5.9 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International journal of epidemiology Pub Date : 2025-06-11 DOI:10.1093/ije/dyaf117

Win Thu, Alana Cavadino, Alistair Woodward, Sandar Tin Tin

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引用次数: 0

Abstract

Background: The choice of transport mode may influence cancer risk by affecting physical activity level, sedentary behaviour, and exposure to environmental pollution. This study investigated the associations between commuting modes and 16 site-specific cancers in the UK Biobank.

Methods: The UK Biobank is a prospective cohort study involving about 500 000 participants. Information on transport modes was collected at recruitment, and incident cancer cases were identified through linkage to national cancer registries. Multivariable Cox proportional hazards models were used.

Results: There were 252 334 employed participants included, and 15 828 incident cancer cases were identified over a median follow-up of 11.7 years. Compared to the car-only mode, cycling (exclusively or combined with any other modes) was associated with a lower risk of colon [hazard ratio (HR): 0.72; 95% confidence interval: 0.53-0.96], renal (HR: 0.60; 0.38-0.96), and stomach (HR: 0.27; 0.10-0.71) cancers. Walking (exclusively or combined with any motorized mode) was associated with a lower risk of renal (HR: 0.67; 0.49-0.92) and liver (HR: 0.55; 0.31-0.98) cancers. Public transport users were less engaged in other physical activities, and its use was associated with a higher risk of bladder cancer (HR: 1.39; 1.01-1.90).

Conclusions: Active commuting, even combined with motorized modes, is associated with a lower risk of some common cancers.

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通勤方式与英国生物银行16种特定地点癌症风险之间的关系。

背景：交通方式的选择可能通过影响身体活动水平、久坐行为和暴露于环境污染来影响癌症风险。这项研究调查了英国生物银行中通勤方式与16种特定地点癌症之间的关系。方法：英国生物银行是一项涉及约50万参与者的前瞻性队列研究。在招募时收集了有关运输方式的信息，并通过与国家癌症登记处的联系确定了癌症病例。采用多变量Cox比例风险模型。结果：在中位随访11.7年期间，共纳入252334名受雇参与者，确定了15828例癌症病例。与只开车的模式相比，骑车（单独或与任何其他模式结合）与较低的结肠风险相关[危险比（HR）： 0.72；95%可信区间：0.53-0.96]，肾脏(HR: 0.60；0.38 ~ 0.96)，胃(HR: 0.27；0.10 - -0.71)癌症。步行（单独或与任何机动模式相结合）与较低的肾脏风险相关(HR: 0.67；0.49-0.92)和肝脏(HR: 0.55；0.31 - -0.98)癌症。公共交通使用者较少从事其他身体活动，使用公共交通与膀胱癌的高风险相关(HR: 1.39；1.01 - -1.90)。结论：积极的通勤，甚至与机动模式相结合，与某些常见癌症的风险降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

13.60

自引率

2.60%

发文量

226

审稿时长

3 months

期刊介绍： The International Journal of Epidemiology is a vital resource for individuals seeking to stay updated on the latest advancements and emerging trends in the field of epidemiology worldwide. The journal fosters communication among researchers, educators, and practitioners involved in the study, teaching, and application of epidemiology pertaining to both communicable and non-communicable diseases. It also includes research on health services and medical care. Furthermore, the journal presents new methodologies in epidemiology and statistics, catering to professionals working in social and preventive medicine. Published six times a year, the International Journal of Epidemiology provides a comprehensive platform for the analysis of data. Overall, this journal is an indispensable tool for staying informed and connected within the dynamic realm of epidemiology.