Endothelium and Systemic Inflammation in Neonates and Children.

Abstract

The endothelium plays a crucial role in maintaining vascular homeostasis. Inflammation is initiated by activation of endothelial cells, which results in endothelial dysfunction. Dysfunction of the endothelium can have significant consequences in neonates and children. It is essential to understand the mechanisms underlying endothelial dysfunction in neonates and paediatric population to develop effective therapy interventions and improve outcomes. The aim of the review is to summarize the recent studies on the endothelium-associated molecules as biomarkers of systemic inflammatory conditions in the neonatal and paediatric population.