Protective Effects of Cedrol on Aging-Induced Cognitive Impairment in Rats.

IF 1.3 4区医学 Q4 GERIATRICS & GERONTOLOGY

Experimental Aging Research Pub Date : 2025-07-09 DOI:10.1080/0361073X.2025.2526998

Fatemeh Ghorbani, Mohammad Amin Forqani, Mahmoud Hosseini, Fatemeh Forouzanfar

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引用次数: 0

Abstract

Purpose: Aging is a gradual alteration in cells and tissues' homeostasis mechanisms. Oxidative stress is an important contributor to aging. This study investigated the effect of cedrol a natural sesquiterpene on rats' memory and oxidative stress markers including malondialdehyde (MDA) and total thiol levels in the hippocampus, cortex, liver, heart, and kidneys of rats and their liver enzymes.

Methods: Twenty-month-old rats were divided into three groups: cedrol 10 mg/kg, cedrol 5 mg/Kg, and saline treatment for 30 consecutive days. A passive avoidance test was performed in the last 3 days. A group of young 8-week rats was also treated with saline as the control group.

Results: The performance of old rats in passive avoidance test memory was impaired compared to young rats. Old rats had increased levels of MDA and decreased total thiol in mentioned tissues compared to young rats. Besides, the AST and ALT liver enzyme levels were higher in old than young rats. Administration of cedrol in old rats improved their performance in the passive avoidance test, decreased the level of MDA, increased total thiol levels, and decreased AST and ALT liver enzymes.

Conclusions: Based on the results, cedrol may probably alleviate aging consequences in rats by reducing oxidative stress.

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雪松醇对衰老大鼠认知功能损伤的保护作用。

目的：衰老是细胞和组织稳态机制的逐渐改变。氧化应激是导致衰老的重要因素。本研究研究了天然倍半萜雪松醇对大鼠海马、皮质、肝脏、心脏和肾脏中丙二醛（MDA）和总硫醇水平及其肝酶的记忆和氧化应激标志物的影响。方法：将20月龄大鼠分为三组：雪松醇10 mg/kg组、雪松醇5 mg/kg组和生理盐水组，连续30 d。最后3天进行被动回避试验。8周龄幼龄大鼠也给予生理盐水处理作为对照组。结果：老年大鼠在被动回避测试记忆中的表现较年轻大鼠有所下降。与年轻大鼠相比，老年大鼠的MDA水平升高，上述组织中的总硫醇含量降低。老龄大鼠AST、ALT肝酶水平高于幼龄大鼠。老年大鼠给予雪松醇可改善其被动回避试验的表现，降低MDA水平，增加总硫醇水平，降低AST和ALT肝酶。结论：雪松醇可能通过降低氧化应激来缓解大鼠的衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Aging Research 医学-老年医学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.