Advanced ionic antibacterial solutions for dental caries prevention with enhanced aesthetic and demineralization functions.

IF 6.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2025-07-07 DOI:10.1016/j.dental.2025.07.002

Yu-Chien Lin, Wan-Rong Lin, Kaiti Chang, Nai-Chia Teng, Jen-Chang Yang, Ren-Jei Chung

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引用次数: 0

Abstract

Silver Diamine Fluoride (SDF) is a widely used agent for non-surgical dental caries treatment, offering effective antibacterial and remineralization benefits. However, its high silver ion concentration often results in black stains on treated surfaces, limiting patient acceptance due to aesthetic concerns. This study introduces a novel anti-caries solution incorporating zinc, titanium, and silicon ions, along with silver nanoparticles, to address these limitations. The formulation enables controlled ion release into dentinal tubules, providing sustained antibacterial effects while minimizing discoloration. It demonstrated superior biocompatibility with L929 and HGF-1 cells and reduced staining compared to SDF. Simulated oral environment tests confirmed its ability to form protective crystals, enhance dentin hardness, and inhibit collagen degradation, effectively suppressing caries progression. This solution offers an improved aesthetic and therapeutic option, particularly benefiting pediatric and special-needs patients.

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先进的离子抗菌溶液预防龋齿，增强美观和脱矿功能。

二胺氟化银（SDF）是一种广泛用于非手术治疗龋齿的药物，具有有效的抗菌和再矿化作用。然而，其高银离子浓度通常会导致治疗表面出现黑色污渍，由于美观问题限制了患者的接受度。本研究介绍了一种新的抗龋溶液，结合锌、钛和硅离子，以及纳米银，以解决这些限制。该配方使控制离子释放到牙本质小管，提供持续的抗菌效果，同时最大限度地减少变色。与SDF相比，它与L929和HGF-1细胞具有良好的生物相容性，并且染色减少。模拟口腔环境试验证实其能够形成保护性结晶，增强牙本质硬度，抑制胶原蛋白降解，有效抑制龋齿进展。这种解决方案提供了一种改进的美学和治疗选择，特别有利于儿科和特殊需要的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.