Single-Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence (Adv. Sci. 26/2025)

IF 14.3 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song
{"title":"Single-Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence (Adv. Sci. 26/2025)","authors":"Yubin Xie,&nbsp;Chen Chen,&nbsp;Fei Wu,&nbsp;Yiman Peng,&nbsp;Jing Su,&nbsp;Yang Zhao,&nbsp;Hongjie Huang,&nbsp;Zhong Alan Li,&nbsp;Yin Pei,&nbsp;Wencui Li,&nbsp;Yi He,&nbsp;Tianchen Xue,&nbsp;Chenxi Cao,&nbsp;Sui Peng,&nbsp;Xin Zhang,&nbsp;Weidong Song","doi":"10.1002/advs.202570198","DOIUrl":null,"url":null,"abstract":"<p><b>Predicting Disease Recurrence</b></p><p>On this cover, bamboo symbolizes the cartilage layer of the knee joint affected by D-TGCT. A bamboo stick insect and a bamboo weevil represent MMP3<sup>+</sup> fibroblasts and IL-1B<sup>+</sup>CCL20<sup>+</sup> macrophages, respectively, gnawing at the bamboo to signify their role in local tissue invasion. This vivid illustration captures the key findings of Yubin Xie, Xin Zhang, Weidong Song, and co-workers, who used single-cell analysis to uncover D-TGCT-specific cellular interactions and identify ROR1 and PRKD1 as biomarkers for disease recurrence. More details can be found in article number 2415835. The cover art was created by <i>Coloring Guangzhou</i>.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 26","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570198","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570198","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Predicting Disease Recurrence

On this cover, bamboo symbolizes the cartilage layer of the knee joint affected by D-TGCT. A bamboo stick insect and a bamboo weevil represent MMP3+ fibroblasts and IL-1B+CCL20+ macrophages, respectively, gnawing at the bamboo to signify their role in local tissue invasion. This vivid illustration captures the key findings of Yubin Xie, Xin Zhang, Weidong Song, and co-workers, who used single-cell analysis to uncover D-TGCT-specific cellular interactions and identify ROR1 and PRKD1 as biomarkers for disease recurrence. More details can be found in article number 2415835. The cover art was created by Coloring Guangzhou.

Abstract Image

单细胞分析阐明腱鞘巨细胞瘤的病理异质性并确定预测疾病复发的生物标志物(Sci. 26/2025)
预测疾病复发在这个封面上,竹子象征着受D-TGCT影响的膝关节软骨层。竹节虫和竹象鼻虫分别代表MMP3+成纤维细胞和IL-1B+CCL20+巨噬细胞,啃食竹子表示它们在局部组织侵袭中的作用。这张生动的插图捕捉了谢玉斌、张欣、宋卫东及其同事的关键发现,他们使用单细胞分析揭示了d - tgct特异性细胞相互作用,并确定了ROR1和PRKD1是疾病复发的生物标志物。更多的细节可以在2415835号文章中找到。封面由着色广州创作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信