Probability of Tumor Lysis Syndrome in Electrochemotherapy of Large Solid Tumors: A Pilot Study

IF 1.8 4区 医学 Q3 HEALTH CARE SCIENCES & SERVICES
Amiradel Larijani, Seyyed Mojtaba Yazdanparast, Farshid Rostami Pouria, Navid Manoochehri, Mahdis Bayat, Sama Mansouri, Nasim Sharghi, Sepideh Mansouri, Omid Nabavian, Fereidoon Memari, Habibollah Mahmoodzadeh, Seyed Rouhollah Miri, Mohammad Abdolahad
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Abstract

Background: Electrochemotherapy (ECT) has emerged as a promising targeted therapy to enhance drug delivery and minimize systemic side effects in cancer patients. However, concerns about tumor lysis syndrome (TLS) and other complications persist, particularly in patients with large solid tumors.

Methods: This study evaluated the clinical outcomes, adverse effects including TLS occurrence and survival rates of ECT in 15 patients with advanced or metastatic solid tumors at Emam Khomeini Hospital from November 2023 to November 2024.

Results: The study included 15 patients (60% female, 40% male) with a median age of 55 years. Tumor types included sarcoma (20%), squamous cell carcinoma (40%), invasive ductal carcinoma (33%), and angiosarcoma (7%). Eleven patients achieved complete remission, while four showed partial response. No cases of stable disease or progression were observed. The mean tumor area reduction was 90%, with an 84% overall survival rate for 3 months. No patients developed TLS, and adverse effects were minimal, with only four patients experiencing transient acidosis post-ECT. There was no significant difference between disease-free survival (DFS) of various tumor types, while recurrent tumors had better DFS in comparison with nonrecurrent ones.

Conclusion: This study confirms ECT as an effective and safe treatment for large solid tumors, with significant tumor regression and no serious complications such as TLS. These findings support ECT as a viable alternative method for patients with primary tumors, inoperable or treatment-resistant ones.

Abstract Image

肿瘤溶解综合征在大实体瘤电化疗中的可能性:一项初步研究
背景:电化疗(ECT)已成为一种很有前途的靶向治疗方法,可以增强癌症患者的药物传递并最大限度地减少全身副作用。然而,对肿瘤溶解综合征(TLS)和其他并发症的担忧仍然存在,特别是在大型实体瘤患者中。方法:本研究评估了2023年11月至2024年11月在霍梅尼医院接受ECT治疗的15例晚期或转移性实体瘤患者的临床结局、不良反应、TLS发生率和生存率。结果:本研究纳入15例患者(女性60%,男性40%),中位年龄55岁。肿瘤类型包括肉瘤(20%)、鳞状细胞癌(40%)、浸润性导管癌(33%)和血管肉瘤(7%)。11例患者完全缓解,4例部分缓解。没有观察到疾病稳定或进展的病例。平均肿瘤面积缩小90%,3个月总生存率84%。没有患者发生TLS,不良反应最小,只有4例患者在ect后出现短暂酸中毒。不同肿瘤类型的无病生存期(DFS)差异无统计学意义,复发肿瘤的DFS优于非复发肿瘤。结论:本研究证实ECT是一种有效、安全的治疗大型实体瘤的方法,肿瘤消退明显,无TLS等严重并发症。这些发现支持ECT作为原发肿瘤,不能手术或治疗抵抗的患者可行的替代方法。
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来源期刊
European Journal of Cancer Care
European Journal of Cancer Care 医学-康复医学
CiteScore
4.00
自引率
4.80%
发文量
213
审稿时长
3 months
期刊介绍: The European Journal of Cancer Care aims to encourage comprehensive, multiprofessional cancer care across Europe and internationally. It publishes original research reports, literature reviews, guest editorials, letters to the Editor and special features on current issues affecting the care of cancer patients. The Editor welcomes contributions which result from team working or collaboration between different health and social care providers, service users, patient groups and the voluntary sector in the areas of: - Primary, secondary and tertiary care for cancer patients - Multidisciplinary and service-user involvement in cancer care - Rehabilitation, supportive, palliative and end of life care for cancer patients - Policy, service development and healthcare evaluation in cancer care - Psychosocial interventions for patients and family members - International perspectives on cancer care
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