In Situ Secondary Self-Assembly of Near-Infrared II J-Aggregates: A Novel Phototheranostic Strategy for Inducing Tumor Pyroptosis (Adv. Mater. 27/2025)

Abstract

Photoimmunotherapy

In article number 2501184, Yuqi Tang, Dan Xiang, and Quan Li report a novel near-infrared II (NIR-II) J-aggregate-based nanomedicine, leveraging an in situ secondary self-assembly strategy to fabricate highly targeted nanoparticles. These nanomedicines trigger pyroptosis by generating type I reactive oxygen species, while simultaneously activating photoimmunotherapy. This unique structural transformation enhances the nanomedicine accumulation in tumor tissues, enabling robust NIR-II fluorescence imaging and improving therapeutic efficacy even in hypoxic tumor microenvironments.