{"title":"Comparative evaluation of amniotic membrane and titanium-prepared platelet-rich fibrin in root coverage: A randomized split-mouth clinical trial","authors":"Devadharshini Chandrasekar, Burnice Nalina Kumari Chellathurai, Jaideep Mahendra, Vijayalakshmi Rajaram","doi":"10.1016/j.jobcr.2025.07.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Gingival recession, particularly Cairo's RT1 and RT2 defects, presents a persistent challenge in periodontal therapy. The comparative effectiveness of soft tissue regenerative materials specifically Amniotic Membrane and Titanium-Prepared Platelet-Rich Fibrin (T-PRF) in the microsurgical management of these defects using the coronally advanced flap (CAF) technique remains inadequately explored.</div></div><div><h3>Aim</h3><div>To clinically evaluate and compare the efficacy of Amniotic Membrane and T-PRF in the treatment of isolated Cairo's RT1 and RT2 gingival recession defects using the CAF technique.</div></div><div><h3>Materials and methods</h3><div>A randomized, split-mouth clinical trial was conducted involving 20 patients with bilateral Cairo's RT1 and RT2 recession defects. A total of 46 sites were treated—23 with Amniotic Membrane (Group A) and 23 with T-PRF (Group B), using the CAF technique under surgical magnification. Clinical parameters assessed at baseline, 90 days, and 180 days included recession depth and width, probing pocket depth, clinical attachment level, width of keratinized gingiva, gingival thickness, and mean root coverage.</div></div><div><h3>Results</h3><div>Both treatment modalities resulted in significant clinical improvements over time. However, Group B (T-PRF) demonstrated statistically superior outcomes in recession depth reduction, clinical attachment level gain, increased keratinized tissue width, greater gingival thickness, and higher mean root coverage compared to Group A (Amniotic Membrane).</div></div><div><h3>Conclusion</h3><div>T-PRF exhibited enhanced regenerative potential over Amniotic Membrane in the management of isolated Cairo's RT1 and RT2 recession defects when used in conjunction with the CAF technique. These findings support the clinical utility of T-PRF as an effective soft tissue grafting material in periodontal plastic surgery.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 5","pages":"Pages 1001-1009"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212426825001460","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Gingival recession, particularly Cairo's RT1 and RT2 defects, presents a persistent challenge in periodontal therapy. The comparative effectiveness of soft tissue regenerative materials specifically Amniotic Membrane and Titanium-Prepared Platelet-Rich Fibrin (T-PRF) in the microsurgical management of these defects using the coronally advanced flap (CAF) technique remains inadequately explored.
Aim
To clinically evaluate and compare the efficacy of Amniotic Membrane and T-PRF in the treatment of isolated Cairo's RT1 and RT2 gingival recession defects using the CAF technique.
Materials and methods
A randomized, split-mouth clinical trial was conducted involving 20 patients with bilateral Cairo's RT1 and RT2 recession defects. A total of 46 sites were treated—23 with Amniotic Membrane (Group A) and 23 with T-PRF (Group B), using the CAF technique under surgical magnification. Clinical parameters assessed at baseline, 90 days, and 180 days included recession depth and width, probing pocket depth, clinical attachment level, width of keratinized gingiva, gingival thickness, and mean root coverage.
Results
Both treatment modalities resulted in significant clinical improvements over time. However, Group B (T-PRF) demonstrated statistically superior outcomes in recession depth reduction, clinical attachment level gain, increased keratinized tissue width, greater gingival thickness, and higher mean root coverage compared to Group A (Amniotic Membrane).
Conclusion
T-PRF exhibited enhanced regenerative potential over Amniotic Membrane in the management of isolated Cairo's RT1 and RT2 recession defects when used in conjunction with the CAF technique. These findings support the clinical utility of T-PRF as an effective soft tissue grafting material in periodontal plastic surgery.
期刊介绍:
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.