Comparative evaluation of amniotic membrane and titanium-prepared platelet-rich fibrin in root coverage: A randomized split-mouth clinical trial

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-07-10 DOI:10.1016/j.jobcr.2025.07.002

Devadharshini Chandrasekar, Burnice Nalina Kumari Chellathurai, Jaideep Mahendra, Vijayalakshmi Rajaram

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引用次数: 0

Abstract

Background

Gingival recession, particularly Cairo's RT1 and RT2 defects, presents a persistent challenge in periodontal therapy. The comparative effectiveness of soft tissue regenerative materials specifically Amniotic Membrane and Titanium-Prepared Platelet-Rich Fibrin (T-PRF) in the microsurgical management of these defects using the coronally advanced flap (CAF) technique remains inadequately explored.

Aim

To clinically evaluate and compare the efficacy of Amniotic Membrane and T-PRF in the treatment of isolated Cairo's RT1 and RT2 gingival recession defects using the CAF technique.

Materials and methods

A randomized, split-mouth clinical trial was conducted involving 20 patients with bilateral Cairo's RT1 and RT2 recession defects. A total of 46 sites were treated—23 with Amniotic Membrane (Group A) and 23 with T-PRF (Group B), using the CAF technique under surgical magnification. Clinical parameters assessed at baseline, 90 days, and 180 days included recession depth and width, probing pocket depth, clinical attachment level, width of keratinized gingiva, gingival thickness, and mean root coverage.

Results

Both treatment modalities resulted in significant clinical improvements over time. However, Group B (T-PRF) demonstrated statistically superior outcomes in recession depth reduction, clinical attachment level gain, increased keratinized tissue width, greater gingival thickness, and higher mean root coverage compared to Group A (Amniotic Membrane).

Conclusion

T-PRF exhibited enhanced regenerative potential over Amniotic Membrane in the management of isolated Cairo's RT1 and RT2 recession defects when used in conjunction with the CAF technique. These findings support the clinical utility of T-PRF as an effective soft tissue grafting material in periodontal plastic surgery.

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羊膜和钛制备的富血小板纤维蛋白在根覆盖中的比较评价：一项随机裂口临床试验

背景牙龈衰退，特别是开罗的RT1和RT2缺陷，是牙周治疗中一个持续的挑战。软组织再生材料，特别是羊膜和钛制备的富血小板纤维蛋白（T-PRF）在冠状推进皮瓣（CAF）技术显微外科治疗这些缺陷方面的比较效果仍未得到充分的探讨。目的临床评价和比较羊膜与T-PRF联合应用CAF技术治疗孤立性Cairo’s RT1和RT2牙龈退缩缺损的疗效。材料与方法对20例双侧Cairo’s RT1和RT2退行性缺损患者进行随机裂口临床试验。采用手术放大下CAF技术对46个部位进行治疗，其中羊膜23个（A组），T-PRF 23个（B组）。在基线、90天和180天评估的临床参数包括退缩深度和宽度、探测袋深度、临床附着水平、角化牙龈宽度、牙龈厚度和平均牙根覆盖率。结果随着时间的推移，两种治疗方式均有显著的临床改善。然而，与A组（羊膜）相比，B组（T-PRF）在衰退深度减少、临床附着水平增加、角化组织宽度增加、牙龈厚度增加和平均根覆盖率更高方面表现出统计学上的优势。结论t - prf与CAF联合使用可增强羊膜的再生潜能，用于治疗分离的Cairo's RT1和RT2衰退缺陷。这些发现支持T-PRF作为一种有效的软组织移植材料在牙周整形手术中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.