Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-07-09 DOI:10.1126/sciadv.adv1182

Honglin Qian, Jing Wang, Zhaohe Dai, Yirong Guo, Ke Liu, Xinyi Li, Meng Hu, Yan Yu, Jiarong Wang, Yuxian Lai, Kefeng Ren, Jian Ji

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Abstract

Biological barriers play a crucial role in safeguarding the human body against pathogens yet pose severe challenges to efficient delivery of therapeutic drugs. Here, we introduce a pressure-driven microinjection (PMI) strategy for the robust and versatile delivery of functional species against biological barriers. With the benefits of elastic porous coating, this strategy enables the capillary suction of drug solutions, localized delivery, and ultrafast penetration through biological barriers by gentle pressure treatment. The penetration capacity is demonstrated by an unprecedented depth (~150 micrometers) of bovine serum albumin (66.4 kilodaltons) across aortic vessels under pressing for only 60 seconds. This spongy coating-based PMI technique can be integrated with medical balloon devices, offering endoluminal treatment within blood vessels, tracheas, and intestines. The in vivo evaluation indicated efficient trans-vascular delivery of 4-octyl itaconate, markedly reducing neointima hyperplasia. This PMI strategy provides a crucial insight for penetrative drug delivery across complex biological barriers.

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压力驱动微注射（PMI）的多孔包被球囊的超快速腔内药物传递跨越生物屏障

生物屏障在保护人体免受病原体侵害方面发挥着至关重要的作用，但也对治疗药物的有效递送构成了严峻的挑战。在这里，我们介绍了一种压力驱动的显微注射（PMI）策略，用于对抗生物屏障的功能物种的稳健和通用递送。利用弹性多孔涂层的优点，该策略可以通过温和的压力处理实现药物溶液的毛细管吸入、局部递送和超快穿透生物屏障。牛血清白蛋白（66.4千道尔顿）在压迫下仅60秒就能以前所未有的深度（约150微米）穿过主动脉血管，这证明了其穿透能力。这种基于海绵状涂层的PMI技术可以与医疗球囊设备集成，在血管、气管和肠道内提供腔内治疗。体内评价表明，4-辛酯衣康酸能有效地经血管输送，显著减少新生内膜增生。这种PMI策略为跨越复杂生物屏障的穿透性药物递送提供了重要见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.