Fungal cues, fibrotic consequences: Commensal sensing by alveolar macrophages promotes pulmonary fibrosis

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-07-09 DOI:10.1016/j.chom.2025.06.015

Paul J. Brennan, Darin L. Wiesner

引用次数: 0

Abstract

In a recent issue of Immunity, Qiu et al. uncover a pivotal role for commensal fungi in promoting lung fibrosis, showing that their interaction with alveolar macrophages triggers a profibrotic transcriptional program through an unconventional Dectin-1-Raf1 signaling axis.

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真菌线索，纤维化后果：肺泡巨噬细胞的共生感应促进肺纤维化

在最近一期的《免疫》杂志上，Qiu等人发现了共生真菌在促进肺纤维化中的关键作用，表明它们与肺泡巨噬细胞的相互作用通过非常规的Dectin-1-Raf1信号轴触发了促纤维化的转录程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.