{"title":"Adjustable weak measurement differential microscopy via flat differentiator","authors":"Yurong Liu, Zhuoxin Zhang, Junfan Zhu, An Wang, Xiong Liu, Rongchun Ge, Zhiyou Zhang","doi":"10.1063/5.0281357","DOIUrl":null,"url":null,"abstract":"Feature extraction and phase retrieval, as critical technical nodes in imaging technologies, play a pivotal role in label-free biological imaging and target recognition. Optical differential imaging is pivotal for extracting phase information in label-free biological imaging and feature extraction, yet existing techniques often suffer from complexity, limited adjustability, and anisotropic signals. Here, we propose an adjustable weak measurement differential microscopy that integrates a flat differentiator with weak measurement to achieve flexible, high-precision phase imaging. By modulating the orientation and incident angle of a uniaxial crystal, we demonstrate tunable spatial differentiation in both strength and direction, enabling isotropic edge detection and phase mining. Furthermore, the system enables rapid switching between optical spatial differentiation and differential interference contrast imaging modes via post-selection state adjustments to accommodate different application scenarios. The results demonstrate this miniaturized, modular approach enables breakthrough capabilities in automated sensing, label-free microscopy, and optical computing systems.","PeriodicalId":8094,"journal":{"name":"Applied Physics Letters","volume":"21 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Physics Letters","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1063/5.0281357","RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Feature extraction and phase retrieval, as critical technical nodes in imaging technologies, play a pivotal role in label-free biological imaging and target recognition. Optical differential imaging is pivotal for extracting phase information in label-free biological imaging and feature extraction, yet existing techniques often suffer from complexity, limited adjustability, and anisotropic signals. Here, we propose an adjustable weak measurement differential microscopy that integrates a flat differentiator with weak measurement to achieve flexible, high-precision phase imaging. By modulating the orientation and incident angle of a uniaxial crystal, we demonstrate tunable spatial differentiation in both strength and direction, enabling isotropic edge detection and phase mining. Furthermore, the system enables rapid switching between optical spatial differentiation and differential interference contrast imaging modes via post-selection state adjustments to accommodate different application scenarios. The results demonstrate this miniaturized, modular approach enables breakthrough capabilities in automated sensing, label-free microscopy, and optical computing systems.
期刊介绍:
Applied Physics Letters (APL) features concise, up-to-date reports on significant new findings in applied physics. Emphasizing rapid dissemination of key data and new physical insights, APL offers prompt publication of new experimental and theoretical papers reporting applications of physics phenomena to all branches of science, engineering, and modern technology.
In addition to regular articles, the journal also publishes invited Fast Track, Perspectives, and in-depth Editorials which report on cutting-edge areas in applied physics.
APL Perspectives are forward-looking invited letters which highlight recent developments or discoveries. Emphasis is placed on very recent developments, potentially disruptive technologies, open questions and possible solutions. They also include a mini-roadmap detailing where the community should direct efforts in order for the phenomena to be viable for application and the challenges associated with meeting that performance threshold. Perspectives are characterized by personal viewpoints and opinions of recognized experts in the field.
Fast Track articles are invited original research articles that report results that are particularly novel and important or provide a significant advancement in an emerging field. Because of the urgency and scientific importance of the work, the peer review process is accelerated. If, during the review process, it becomes apparent that the paper does not meet the Fast Track criterion, it is returned to a normal track.