Association of CRP Albumin Ratio with No-Reflow Phenomenon After PCI: A Systematic Review and Meta-Analysis.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir Pub Date : 2025-07-07 DOI:10.5543/tkda.2025.17257

Mustafa Bilal Özbay, Serhat Değirmen, Ayşenur Güllü, Bede Nnaemeka Nriagu, Yasin Özen, Çağrı Yayla

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Abstract

Objective: No-reflow (NR), a complication of percutaneous coronary intervention (PCI), is associated with poor cardiovascular outcomes. Identifying reliable predictors of NR is crucial for risk stratification and improving clinical outcomes. The CRP-albumin ratio (CAR), a marker of systemic inflammation, has been suggested as a potential predictor of NR. This systematic review and meta-analysis aimed to evaluate the relationship of CAR with the NR after PCI.

Methods: A comprehensive literature search was conducted in Cochrane, Embase and PubMed databases, following PRISMA 2020 guidelines. Studies evaluating the predictive value of CAR for NR were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using Cochrane's Q and I² statistics.

Results: Four studies comprising 2,068 patients were included. The pooled analysis showed a significant association between higher CAR and an increased risk of NR (OR: 2.34; 95% CI: 1.19-4.60; p = 0.01; I² = 96%).

Conclusion: We found that elevated CAR is associated with NR after PCI, suggesting its potential utility as a prognostic biomarker. However, high heterogeneity underscores the need for large-scale studies to validate its clinical applicability.

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CRP白蛋白比率与PCI术后无血流现象的关系：系统回顾和荟萃分析。

目的：无回流（NR）是经皮冠状动脉介入治疗（PCI）的并发症，与不良心血管预后相关。确定可靠的NR预测因子对于风险分层和改善临床结果至关重要。crp -白蛋白比率（CAR）是全身性炎症的标志，已被认为是NR的潜在预测因子。本系统综述和荟萃分析旨在评估PCI术后CAR与NR的关系。方法：按照PRISMA 2020指南，在Cochrane、Embase和PubMed数据库中进行全面的文献检索。包括评价CAR对NR预测价值的研究。采用随机效应模型计算95%置信区间（ci）的合并优势比（ORs）。采用Cochrane's Q和I²统计量评估异质性。结果：纳入4项研究，共2068例患者。合并分析显示，较高的CAR与NR风险增加之间存在显著关联(OR: 2.34；95% ci: 1.19-4.60；P = 0.01；I²= 96%)。结论：我们发现CAR升高与PCI术后NR相关，提示其作为预后生物标志物的潜在效用。然而，高异质性强调需要大规模研究来验证其临床适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

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