Post-Movement Beta Rebound for Longitudinal Monitoring of Motor Rehabilitation in Stroke Patients Using an Exoskeleton-Assisted Paradigm.

Abstract

Task-oriented rehabilitation is essential for hand function recovery in stroke patients, and recent advancements in BCI-controlled exoskeletons and neural biomarkers - such as post-movement beta rebound (PMBR) - offer new pathways to optimize these therapies. Movement-related EEG signals from the sensorimotor cortex, particularly PMBR (post-movement) and event-related desynchronization (ERD, during movement), exhibit high task specificity and correlate with stroke severity. This study evaluated PMBR in 34 chronic stroke patients across two cohorts, along with a control group of 16 healthy participants, during voluntary and exoskeleton-assisted movement tasks. Longitudinal tracking in the second cohort enabled the analysis of PMBR changes, with EEG recordings acquired at three timepoints over a 30-session rehabilitation program. Findings revealed significant PMBR alterations in both passive and active movement tasks: patients with severe impairment lacked a PMBR dipole in the ipsilesional hemisphere, while moderately impaired patients showed a diminished response. The marked differences in PMBR patterns between stroke patients and controls highlight the extent of sensorimotor cortex disruption due to stroke. ERD showed minimal task-specific variation, underscoring PMBR as a more reliable biomarker of motor function impairment. These findings support the use of PMBR, particularly the PMBR/ERD ratio, as a biomarker for EEG-guided monitoring of motor recovery over time during exoskeleton-assisted rehabilitation.