Efficacy of Omega-3 supplementation in olfactory dysfunction: a systematic review of randomized controlled trials.

IF 2.2 Q3 NUTRITION & DIETETICS

BMC Nutrition Pub Date : 2025-07-07 DOI:10.1186/s40795-025-01114-1

Raghad S Alzahrani, Taif F Alkhatabi, Abdulaziz F Bokhari, Wed M Ismail, Abdullah S Alyamani, Ali S Alsudais, Bassam AlRajhi, Dakheelallah M Almutairi

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Abstract

Background: Olfactory dysfunction (OD) significantly impacts patients' quality of life, yet effective treatments are limited. Omega-3 fatty acids have shown promise in improving olfactory function, but further research is needed to evaluate their efficacy.

Aims/objectives: This systematic review aimed to assess the effects of omega-3 supplementation on OD.

Methods: A comprehensive search identified randomized controlled trials investigating omega-3 supplementation in OD patients. Inclusion criteria involved adult patients receiving omega-3 fatty acids and undergoing olfactory function assessments.

Results: Three studies with 175 participants were included. Two studies reported omega-3's protective effect against olfactory loss over three months. However, a trial on COVID-19 patients found no significant improvement in olfactory function.

Conclusions: Omega-3 supplementation, along with olfactory training or nasal rinses, appears to improve olfactory function in OD patients. However, further research is needed to evaluate its standalone efficacy. Omega-3 fatty acids offer a potential therapy for OD, warranting optimization and long-term effects investigation.

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补充Omega-3对嗅觉功能障碍的疗效：随机对照试验的系统回顾。

背景：嗅觉功能障碍（OD）显著影响患者的生活质量，但有效的治疗方法有限。Omega-3脂肪酸已经显示出改善嗅觉功能的希望，但还需要进一步的研究来评估其功效。目的/目的：本系统综述旨在评估omega-3补充剂对OD的影响。方法：一项全面的研究确定了调查omega-3补充剂在OD患者中的作用的随机对照试验。纳入标准包括接受omega-3脂肪酸治疗并进行嗅觉功能评估的成年患者。结果：纳入3项研究，共175名受试者。两项研究报告了omega-3在三个月内对嗅觉丧失的保护作用。然而，一项针对COVID-19患者的试验发现，嗅觉功能没有明显改善。结论：Omega-3补充剂，以及嗅觉训练或鼻冲洗，似乎可以改善OD患者的嗅觉功能。然而，需要进一步的研究来评估其单独的疗效。Omega-3脂肪酸提供了潜在的治疗OD的方法，值得优化和长期效果的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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