Characterization of Pulmonary Sclerosing Pneumocytoma Assessed by ¹⁸F-FDG PET/CT.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2025-07-01 DOI:10.1111/1759-7714.70124

Jie Xu, Xing Wan, Shudan Zhai, Shuai Yuan, Songyi Li, Wengui Xu, Mengran Fan, Lei Zhu

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引用次数: 0

Abstract

Background: This study evaluated the presentation of pulmonary sclerosing pneumocytoma (PSP) in ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) with the aim of increasing awareness of the disease.

Methods: Retrospective analysis was performed on 46 PSP patients who had ¹⁸F-FDG PET/CT before surgery or pathological examination from January 2011 to December 2023. The ¹⁸F-FDG PET/CT manifestations of PSP were summarized, and the correlation between the maximum diameter of the tumor and PET metabolic parameters was analyzed, including the maximum standardized uptake value (SUV_max), the mean SUV (SUV_mean), the peak SUV (SUV_peak), metabolic tumor volume (MTV) and total lesion glycolysis (TLG).

Results: The 46 tumors were randomly distributed in each lobe of both lungs. The mean maximum diameter of these lesions was 2.2 cm (range: 0.6 to 6.5 cm). The mean SUV_max was 2.96 ± 1.88 (median: 2.69, range: 0-9.02). Thirty-three cases were categorized as mild to moderate FDG uptake, eleven cases were categorized as intense FDG uptake, and no FDG uptake was observed in the remaining two cases of the lesions qualitatively evaluated. The SUV_max of the PSP showed a positive correlation with the maximum diameter of the tumors (R = 0.493, R² = 0.258, and p < 0.001). SUV_mean (R = 0.500, R² = 0.259, p < 0.001), SUV_peak (R = 0.553, R² = 0.324, p < 0.001), MTV (R = 0.773, R² = 0.592, p < 0.001) and TLG (R = 0.800, R² = 0.654, p < 0.001) were positively correlated with the maximum diameter of the tumor.

Conclusion: In our study, statistically significant positive correlations were found between SUV_max, SUV_mean, SUV_peak, MTV, and TLG and the maximum diameter of PSP. We found that the maximum diameter of the tumor is associated with an increase in FDG uptake in PSP, reflecting a potential correlation between lesion diameter and PET metabolic parameters, indicating a link between structural features and metabolic activity.

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18F-FDG PET/CT评价肺硬化性肺细胞瘤的特征。

背景：本研究评估肺硬化性肺细胞瘤（PSP）在18f -氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）上的表现，目的是提高对该疾病的认识。方法：回顾性分析2011年1月至2023年12月46例PSP患者术前或病理检查均行18F-FDG PET/CT检查的资料。总结PSP的18F-FDG PET/CT表现，分析肿瘤最大直径与PET代谢参数的相关性，包括最大标准化摄取值（SUVmax）、平均SUV （SUVmean）、峰值SUV （SUVpeak）、代谢肿瘤体积（MTV）和病变总糖酵解（TLG）。结果：46例肿瘤随机分布于双肺各叶。这些病变的平均最大直径为2.2厘米（范围：0.6至6.5厘米）。平均SUVmax为2.96±1.88（中位数：2.69，范围：0-9.02）。33例为轻至中度FDG摄取，11例为强烈FDG摄取，其余2例定性评价病变未观察到FDG摄取。PSP的SUVmax与肿瘤最大直径呈正相关（R = 0.493, R2 = 0.258, p mean）（R = 0.500, R2 = 0.259, p peak）（R = 0.553, R2 = 0.324, p 2 = 0.592, p 2 = 0.654, p）。结论：在我们的研究中，SUVmax、SUVmean、SUVpeak、MTV、TLG与PSP最大直径呈正相关，具有统计学意义。我们发现肿瘤的最大直径与PSP中FDG摄取的增加有关，反映了病变直径与PET代谢参数之间的潜在相关性，表明结构特征与代谢活性之间存在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.