Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults.

IF 5.8 1区医学 Q1 PSYCHIATRY

Translational Psychiatry Pub Date : 2025-07-07 DOI:10.1038/s41398-025-03443-y

Yingjie Shi, Nina Roth Mota, Barbara Franke, Emma Sprooten

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Abstract

Psychiatric conditions, known for their hereditary nature, exert significant impacts on various life domains. Leveraging this heritability, we examine the relations between genetic susceptibility to major psychiatric disorders and the multifaceted aspects of quality of life in two population-based cohorts, the Adolescent Brain Cognitive Development (ABCD) study (N = 3909 preadolescent children) and the UK Biobank (N = 269,293 adults). Genetic susceptibility to seven major psychiatric disorders was quantified by polygenic scores derived from extensive genome-wide association studies (N = 21,000-413,000). Pervasive associations were found between genetic risk for all seven major psychiatric disorders investigated and age-relevant real-life quality of life indices, with varied patterns of associations for different life domains. We especially highlight the role of genetic risks for ADHD and major depressive disorders. Our findings emphasize the continuous nature of psychiatric traits, extending their influence on daily life experiences and societal functioning beyond symptomatology and diagnostic classifications.

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对重大精神疾病的遗传倾向对儿童和成人的生活质量结果有多方面的影响。

精神疾病以其遗传性质而闻名，对各种生活领域产生重大影响。利用这种遗传性，我们在两个基于人群的队列中研究了主要精神疾病的遗传易感性与生活质量的多方面之间的关系，即青少年大脑认知发展（ABCD）研究（N = 3909名青春期前儿童）和英国生物银行（N = 269,293名成年人）。通过广泛的全基因组关联研究（N = 21,000-413,000）得出的多基因评分来量化七种主要精神疾病的遗传易感性。研究发现，所有七种主要精神疾病的遗传风险与年龄相关的现实生活质量指数之间存在普遍关联，不同的生活领域存在不同的关联模式。我们特别强调ADHD和重度抑郁症的遗传风险的作用。我们的研究结果强调了精神特征的连续性，将其对日常生活经历和社会功能的影响扩展到症状学和诊断分类之外。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.