{"title":"[Is the megaesophagus test valid for White Swiss Shepherds (Berger Blanc Suisse)?]","authors":"A Kehl, C Schelling","doi":"10.17236/sat00460","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Gene tests play an important role for controlling monogenetic diseases because they reveal a genotype for each tested dog and thereby allow for the selection of animals with a lower genetic burden. For some complex inherited diseases and anomalies so called risk-tests are available and may support the selection of breeding animals. They analyze DNA-sequence variants which render a higher risk for carriers to develop a disease or anomaly. The usefulness of a risk-test for congenital idiopathic megaoesophagus (CIM-test) in German shepherds was analyzed in the closely related breed of White Swiss shepherds. The results showed clearly that the CIM-test in this breed is almost not informative, and a selection would probably not reduce the prevalence but only lower the genetic variability. Breeders and owners should be informed accordingly.</p>","PeriodicalId":21544,"journal":{"name":"Schweizer Archiv fur Tierheilkunde","volume":"167 7","pages":"412-416"},"PeriodicalIF":0.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schweizer Archiv fur Tierheilkunde","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.17236/sat00460","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Gene tests play an important role for controlling monogenetic diseases because they reveal a genotype for each tested dog and thereby allow for the selection of animals with a lower genetic burden. For some complex inherited diseases and anomalies so called risk-tests are available and may support the selection of breeding animals. They analyze DNA-sequence variants which render a higher risk for carriers to develop a disease or anomaly. The usefulness of a risk-test for congenital idiopathic megaoesophagus (CIM-test) in German shepherds was analyzed in the closely related breed of White Swiss shepherds. The results showed clearly that the CIM-test in this breed is almost not informative, and a selection would probably not reduce the prevalence but only lower the genetic variability. Breeders and owners should be informed accordingly.
期刊介绍：
Das Schweizer Archiv für Tierheilkunde ist die älteste veterinärmedizinische Zeitschrift der Welt (gegründet 1816). Es ist das wissenschaftliche und praxisbezogene offizielle Publikationsorgan der Gesellschaft Schweizer Tierärztinnen und Tierärzte.
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