Corneal Densitometry and Higher Order Aberrations After Corneal Transplantation and Corneal Cross-Linking for Keratoconus: 3-Year Results.

IF 3 3区医学 Q1 OPHTHALMOLOGY

Journal of refractive surgery Pub Date : 2025-07-01 DOI:10.3928/1081597X-20250515-08

Tong Chen, Mingna Liu, Yue Lin, Ge Tian, Chang Liu, Xiaohui Wu, Suxia Li, Xiaolin Qi, Ting Wang, Berthold Seitz, Weiyun Shi, Hua Gao

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引用次数: 0

Abstract

Purpose: To compare the corneal densitometry and higher order aberrations (HOAs) following corneal cross-linking (CXL), deep anterior lamellar keratoplasty (DALK), and minimally invasive lamellar keratoplasty (MILK) for keratoconus.

Methods: Twenty-five eyes treated with CXL (CXL group), 17 eyes treated with DALK (DALK group), and 25 eyes treated with MILK (MILK group) were included in this prospective study. Corneal densitometry and HOAs were evaluated preoperatively and at 1, 3, 6, 12, 24, and 36 months postoperatively.

Results: In CXL and MILK, corneal densitometry values peaked at 1 month (P < .001), returned to the preoperative level at 6 months (P = .334, 0.224), and declined below baseline at 36 months (P < .001, P = .129); the changes from preoperatively to 36 months postoperatively between groups were not significant (P = .713). In DALK, corneal densitometry values were still higher at 36 months than before surgery (P = .007). The root mean square value of total HOAs from the whole cornea was decreased by 0.192 ± 0.457, 0.823 ± 0.926, and 3.938 ± 1.873 µm at 36 months postoperatively for CXL, MILK, and DALK, respectively (P = .047, <.001, <.001); the differences between groups were all statistically significant. The total HOA or spherical aberration changes from the whole cornea correlated with maximum keratometry changes for CXL (P < .001; R² = 0.490), MILK (P < .001; R² = 0.599), and DALK (P < .001; R² = .558).

Conclusions: MILK and CXL showed a similar improvement in corneal densitometry. HOAs improved most in DALK, followed by MILK and CXL, corresponding to maximum keratometry changes. The coma and spherical aberrations improved in MILK and DALK, but not in CXL. [J Refract Surg. 2025;41(7):e715-e723.].

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角膜密度测量和高阶像差角膜移植和角膜交联圆锥角膜：3年的结果。

目的：比较角膜交联（CXL）、深前板层角膜移植术（DALK）和微创板层角膜移植术（MILK）治疗圆锥角膜后角膜密度测定和高阶像差（HOAs）的变化。方法：采用CXL治疗25只眼（CXL组），DALK治疗17只眼（DALK组），MILK治疗25只眼（MILK组）进行前瞻性研究。术前及术后1、3、6、12、24、36个月评估角膜密度测定和hoa。结果：CXL和MILK患者角膜密度测量值在1个月时达到峰值（P < 0.001）， 6个月时恢复到术前水平（P = 0.334, 0.224）， 36个月时下降到基线以下（P < 0.001, P = 0.129）；术前至术后36个月组间差异无统计学意义（P = .713）。在DALK中，角膜密度测量值在36个月时仍高于术前（P = .007）。CXL、MILK、DALK术后36个月全角膜总hoa均方根值分别下降0.192±0.457、0.823±0.926、3.938±1.873µm (P = 0.047, P < 0.001；R2 = 0.490)、牛奶(p < 0.001；R2 = 0.599), DALK (P < 0.001；R2 = .558)。结论：MILK和CXL对角膜密度测量有相似的改善。DALK的HOAs改善最多，其次是MILK和CXL，对应于最大的角膜测量变化。MILK组和DALK组的彗差和球差均有改善，CXL组无改善。[J].中华眼科杂志，2015;41(7):715- 723。

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来源期刊

$Journal of refractive surgery$

Journal of refractive surgery 医学-外科

CiteScore

5.10

自引率

12.50%

发文量

160

审稿时长

4-8 weeks

期刊介绍： The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.