Preventable Cancers Caused by Infection in Korea From 2015 to 2030.

IF 2.3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Sungji Moon, Jeoungbin Choi, Soseul Sung, Youjin Hong, Kwang-Pil Ko, Jung Eun Lee, Inah Kim, Seungho Ryu, Sun Ha Jee, Guen Hui Kim, Sun Young Yang, Aesun Shin, Sun-Seog Kweon, Jeongseon Kim, Jieun Jang, Sangjun Lee, Kyungsik Kim, Woojin Lim, Yoon-Jung Choi, Jeong-Soo Im, Hong Gwan Seo, Sue K Park
{"title":"Preventable Cancers Caused by Infection in Korea From 2015 to 2030.","authors":"Sungji Moon, Jeoungbin Choi, Soseul Sung, Youjin Hong, Kwang-Pil Ko, Jung Eun Lee, Inah Kim, Seungho Ryu, Sun Ha Jee, Guen Hui Kim, Sun Young Yang, Aesun Shin, Sun-Seog Kweon, Jeongseon Kim, Jieun Jang, Sangjun Lee, Kyungsik Kim, Woojin Lim, Yoon-Jung Choi, Jeong-Soo Im, Hong Gwan Seo, Sue K Park","doi":"10.3346/jkms.2025.40.e143","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To contribute to evidence-based cancer prevention policies, we conducted a systematic assessment to estimate the burden of infection-related cancers in South Korea. We estimated the population-attributable fraction (PAF) of each cancer attributable to the causally related infectious agents between 2015 and 2030.</p><p><strong>Methods: </strong>The relative risks of cancer due to infectious agents were calculated using a meta-analysis of results from large-scale Korean cohort studies combined with results from a systematic review of South Korean studies. We calculated the attributable cancer incidence and mortality in 2015 and 2020 from nationwide cancer statistics, assuming a 15-year latency period, and projected them for 2025 and 2030.</p><p><strong>Results: </strong>The estimated attributable cancer cases were 28,420 (13.18%) in 2015 and 26,368 (10.70%) in 2020 for all new cancer cases due to infectious agents. Attributable cancer deaths were 11,292 (14.74%) in 2015 and 9,969 (12.15%) in 2020 for all new cancer mortalities. <i>Helicobacter pylori</i> occupied the largest proportion of cancer incidence (5.93%), followed by hepatitis B virus (HBV) (2.45%) and human papillomavirus (HPV) (1.74%), and the first cause of cancer death was HBV (5.24%), followed by <i>H. pylori</i> (4.62%) and HPV (1.41%) in 2020. The PAFs were predicted to decline to 9.35% (2025) and 8.99% (2030) for incidence, and to 10.18% (2025) and 10.02% (2030) for mortality.</p><p><strong>Conclusion: </strong>Fractions of cancer cases and mortality due to infectious agents are projected to decrease from 2015 to 2030. There should be adequate intervention from authorities to control <i>H. pylori</i>, HBV, and HPV and to reduce the cancer burden.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 26","pages":"e143"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235194/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3346/jkms.2025.40.e143","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: To contribute to evidence-based cancer prevention policies, we conducted a systematic assessment to estimate the burden of infection-related cancers in South Korea. We estimated the population-attributable fraction (PAF) of each cancer attributable to the causally related infectious agents between 2015 and 2030.

Methods: The relative risks of cancer due to infectious agents were calculated using a meta-analysis of results from large-scale Korean cohort studies combined with results from a systematic review of South Korean studies. We calculated the attributable cancer incidence and mortality in 2015 and 2020 from nationwide cancer statistics, assuming a 15-year latency period, and projected them for 2025 and 2030.

Results: The estimated attributable cancer cases were 28,420 (13.18%) in 2015 and 26,368 (10.70%) in 2020 for all new cancer cases due to infectious agents. Attributable cancer deaths were 11,292 (14.74%) in 2015 and 9,969 (12.15%) in 2020 for all new cancer mortalities. Helicobacter pylori occupied the largest proportion of cancer incidence (5.93%), followed by hepatitis B virus (HBV) (2.45%) and human papillomavirus (HPV) (1.74%), and the first cause of cancer death was HBV (5.24%), followed by H. pylori (4.62%) and HPV (1.41%) in 2020. The PAFs were predicted to decline to 9.35% (2025) and 8.99% (2030) for incidence, and to 10.18% (2025) and 10.02% (2030) for mortality.

Conclusion: Fractions of cancer cases and mortality due to infectious agents are projected to decrease from 2015 to 2030. There should be adequate intervention from authorities to control H. pylori, HBV, and HPV and to reduce the cancer burden.

Abstract Image

Abstract Image

Abstract Image

从2015年到2030年韩国可预防的感染癌症
背景:为了促进以证据为基础的癌症预防政策,我们对韩国感染相关癌症的负担进行了系统评估。我们估计了2015年至2030年间由因果相关感染因子导致的每种癌症的人口归因比例(PAF)。方法:利用大规模韩国队列研究结果的荟萃分析,结合韩国研究的系统评价结果,计算感染因子导致癌症的相对风险。我们根据全国癌症统计数据,假设15年的潜伏期,计算2015年和2020年的癌症归因发病率和死亡率,并预测2025年和2030年。结果:2015年因感染源导致的新发癌症病例估计为28420例(13.18%),2020年估计为26368例(10.70%)。在所有新发癌症死亡中,2015年可归因癌症死亡人数为11,292人(14.74%),2020年为9,969人(12.15%)。在2020年癌症发病中,幽门螺杆菌占比最大(5.93%),其次是乙型肝炎病毒(HBV)(2.45%)和人乳头瘤病毒(HPV)(1.74%),导致癌症死亡的第一原因是HBV(5.24%),其次是幽门螺杆菌(4.62%)和HPV(1.41%)。预计paf的发病率将分别降至9.35%(2025年)和8.99%(2030年),死亡率将分别降至10.18%(2025年)和10.02%(2030年)。结论:2015 - 2030年,我市因感染源导致的癌症病例比例和死亡率将呈下降趋势。当局应该采取适当的干预措施来控制幽门螺杆菌、HBV和HPV,并减少癌症负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Korean Medical Science
Journal of Korean Medical Science 医学-医学:内科
CiteScore
7.80
自引率
8.90%
发文量
320
审稿时长
3-6 weeks
期刊介绍: The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信