Yingquan Liu, Yu Ye, Lin Bai, Fan Dai, Xingxing Su, Peijia Hu, Hongliang Cheng
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引用次数: 0
Abstract
Objective: This study explores potential therapeutic strategies by determining the current research status, hotspots, and development trends through bibliometric analysis of the PI3K/Akt in ischemic stroke (IS).
Methods: We searched the Web of Science Core Collection for publications on IS and the PI3K/Akt pathway, covering January 1, 2010, to December 31, 2024. VOSviewer and CiteSpace software were used to analyze research hotspots and cutting-edge topics in the field and generate visual maps of relevant countries, institutions, authors, journals, keywords, and references.
Results: A total of 635 publications were analyzed. The number of publications indicates a steady annual increase in research output. China, Capital Medical University, and Wang Lei were identified as the most prolific country, institution, and author, respectively. The top three contributing journals were Brain Research, Journal of Ethnopharmacology, and Frontiers in Pharmacology. Autophagy, microglia and neuroinflammation, bioinformatics approaches, and traditional Chinese medicine (TCM) are not only current research areas but also important trends for future research. Notably, targeting IS with TCM holds significant potential for translating basic research findings into clinical applications.
Conclusion: This bibliometric analysis provides an in-depth overview of research on the PI3K/Akt pathway in IS, revealing current research status, hotspots, and future research trends. This will provide valuable guidance and direction for developing novel therapeutic strategies targeting this pathway.
目的：本研究通过对缺血性脑卒中（IS）中PI3K/Akt的文献计量学分析，确定其研究现状、热点和发展趋势，探讨潜在的治疗策略。方法：我们检索了Web of Science Core Collection，检索了2010年1月1日至2024年12月31日期间关于IS和PI3K/Akt通路的出版物。利用VOSviewer和CiteSpace软件对该领域的研究热点和前沿话题进行分析，生成相关国家、机构、作者、期刊、关键词和参考文献的可视化地图。结果：共分析635篇文献。出版物的数量表明研究产出每年稳步增长。中国、首都医科大学和王磊分别被评为最多产的国家、机构和作者。贡献排名前三的期刊分别是Brain Research、Journal of Ethnopharmacology和Frontiers in Pharmacology。自噬、小胶质细胞与神经炎症、生物信息学方法、中药等不仅是当前的研究领域，也是未来研究的重要方向。值得注意的是，用中药靶向IS具有将基础研究成果转化为临床应用的巨大潜力。结论：本文通过文献计量学分析，对IS中PI3K/Akt通路的研究进行了深入的综述，揭示了IS的研究现状、热点和未来的研究趋势。这将为开发针对这一途径的新治疗策略提供有价值的指导和方向。
期刊介绍：
Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.
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