Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan.

IF 2.8 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental Toxicology and Chemistry Pub Date : 2025-10-01 DOI:10.1093/etojnl/vgaf172

Cindy Shin Ly Yeoh, Layan Abdulilah Alrazihi, Siew Tung Wong, Shew Fung Wong

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引用次数: 0

Abstract

Research on toxicity, removal, and degradation of per- and polyfluoroalkyl substances (PFAS) has increased tremendously in the number of publications in recent years. The aim of this review was to summarize the source, exposure route, and potential toxicological effects of PFAS to humans. Relevant articles published between 2010 and 2022 were selected from PubMed and Scopus on the PFAS occurrence, exposure route, and potential toxicity effects on human health. This review discusses the potential exposure pathways to PFAS across various life stages, including contaminated food, drinking water, breastfeeding, indoor or outdoor air, and PFAS-containing consumer products. Furthermore, this paper highlights the possible associations between PFAS exposure and various health effects, and the mechanisms underlying these toxicological effects, including immune dysregulation and respiratory impacts, endocrine system disruptions (thyroid and pancreatic functions), lipid and metabolic dysregulation, systemic toxicities affecting the liver, cardiovascular system, and kidneys, as well as adverse reproductive and developmental outcomes, and the nervous system.

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全氟和多氟烷基物质（PFAS）与人类健康：全寿命暴露途径和潜在毒性综述。

近年来，关于全氟烷基和多氟烷基物质（PFAS）的毒性、去除和降解的研究在出版物数量上急剧增加。本综述的目的是总结PFAS的来源、暴露途径和对人类的潜在毒理学影响。从Pubmed和Scopus中选取2010 - 2022年间发表的有关PFAS的发生、暴露途径以及对人体健康的潜在毒性影响的相关文章。这篇综述讨论了PFAS在不同生命阶段的潜在暴露途径，包括受污染的食物、饮用水、母乳喂养、室内或室外空气以及含PFAS的消费品。此外，本文强调了PFAS暴露与各种健康影响之间的可能关联，以及这些毒理学影响的机制，包括免疫失调和呼吸影响，内分泌系统干扰（甲状腺和胰腺功能），脂质和代谢失调，影响肝脏，心血管系统，肾脏的全身毒性，以及不利的生殖和发育结果，以及神经系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Toxicology and Chemistry 环境科学-毒理学

CiteScore

7.40

自引率

9.80%

发文量

265

审稿时长

3.4 months

期刊介绍： The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...] Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.