Increased risk of heart failure among patients with bullous pemphigoid: A nationwide cohort study.

IF 2.7 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2025-07-07 DOI:10.1159/000547272

Tai-Li Chen, Wan-Ting Huang, Chen-Yi Wu, Ching-Hui Loh, Huei-Kai Huang, Ching-Chi Chi

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引用次数: 0

Abstract

Background: Bullous pemphigoid (BP) and heart failure (HF) share similar mechanisms involving chronic inflammation. Nevertheless, the association of BP with HF has been unclear. This study aimed to investigate the association of BP with incident HF.

Methods: We conducted a nationwide cohort study included adults aged ≥ 20 years from Taiwan's National Health Insurance Research Database between 2011 and 2019. Adults with newly-diagnosed BP and matched controls were included. A Cox regression model considering stabilized inverse probability weighting was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident HF in association with BP. Stratified analyses according to age and sex were conducted. Multiple sensitivity analyses were also performed.

Results: Among 39,835 subjects, 975 patients in the BP cohort and 2,311 patients in the non-BP cohort developed HF, with incidence rates of 46.1 and 16.9 per 1,000 person-years, respectively. Adults with BP had a significantly increased risk of incident HF (HR 2.63; 95% CI 2.44-2.83) compared to those without BP. The association remained significant in the age- and sex-stratified analyses. Multiple sensitivity analyses confirmed the robustness of our primary analyses.

Conclusion: BP is associated with an increased risk for HF. Early detection of HF and cardiology consultation among patients with BP presenting relevant symptoms may be implicated in the current practice.

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大疱性类天疱疮患者心力衰竭风险增加：一项全国性队列研究。

背景：大疱性类天疱疮（BP）和心力衰竭（HF）具有相似的慢性炎症机制。然而，血压与心衰的关系尚不清楚。本研究旨在探讨BP与心衰的关系。包括新诊断为BP的成年人和匹配的对照组。采用考虑稳定逆概率加权的Cox回归模型来估计突发心衰与BP相关的风险比（hr）和95%置信区间（ci）。按年龄和性别进行分层分析。还进行了多重敏感性分析。结果：在39835名受试者中，975名BP队列患者和2311名非BP队列患者发生HF，发病率分别为46.1和16.9 / 1000人-年。成年BP患者发生HF的风险显著增加(HR 2.63；95% CI 2.44-2.83)。在年龄和性别分层分析中，这种关联仍然是显著的。多重敏感性分析证实了我们初步分析的稳健性。结论：血压升高与心衰风险增加有关。在出现相关症状的BP患者中早期发现HF和心脏病学咨询可能与当前的实践有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.