{"title":"Connexin 43 and Atypical Chemokine Receptor 3 in Peripheral Blood Mononuclear Cells of Patients With Aneurysmal Subarachnoid Hemorrhage.","authors":"Jian Yan, DianDa Chen, JinLin Xiao, XuYe Wu, ErMing Zeng, Tao Hong, Jian Duan","doi":"10.1177/00033197251350186","DOIUrl":null,"url":null,"abstract":"<p><p>The expression levels of connexin 43 (Cx43) and atypical chemokine receptor 3 (ACKR3) in peripheral blood mononuclear cells (PBMCs) of patients with aneurysmal subarachnoid hemorrhage (aSAH) and their predictive value for cerebral vasospasm (CVS) were retrospectively analyzed. A total of 131 patients with aSAH were included in this study (49 males and 82 females) all of whom had headache as the first manifestation. The results showed that the mRNA expression of Cx43 and ACKR3 in PBMCs of patients with aSAH was significantly increased. The results of ROC curve showed that the combination of the two indicators was expected to assist clinical judgement in predicting the occurrence of CVS in patients with aSAH, which could be helpful for screening patients with high risk of CVS.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":" ","pages":"33197251350186"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00033197251350186","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
The expression levels of connexin 43 (Cx43) and atypical chemokine receptor 3 (ACKR3) in peripheral blood mononuclear cells (PBMCs) of patients with aneurysmal subarachnoid hemorrhage (aSAH) and their predictive value for cerebral vasospasm (CVS) were retrospectively analyzed. A total of 131 patients with aSAH were included in this study (49 males and 82 females) all of whom had headache as the first manifestation. The results showed that the mRNA expression of Cx43 and ACKR3 in PBMCs of patients with aSAH was significantly increased. The results of ROC curve showed that the combination of the two indicators was expected to assist clinical judgement in predicting the occurrence of CVS in patients with aSAH, which could be helpful for screening patients with high risk of CVS.
期刊介绍：
A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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